Methyl 2-[formyl(methyl)amino]benzoate | 424821-05-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2-[formyl(methyl)amino]benzoate
• CAS: 424821-05-6
• 化学式: C₁₀H₁₁NO₃
• 分子量: 193.202
• InChiKey: NSNNXPCDSMGAPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-甲基喹啉 、 Methyl 2-[formyl(methyl)amino]benzoate 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 以51%的产率得到1-methyl-3-(2-quinolyl)-1,4-dihydro-4-quinolone
  参考文献：
  名称：

  2,3'-联喹啉的研究23.克莱森缩合反应合成1'-R-1'，4'-二氢-2,3'-联喹啉-4'-酮。

  摘要：

  A method has been developed for the synthesis of 1'-R-1',4'-dihydro-2,3'-biquinolin-4'-ones based on the interaction of quinaldine with N-alkyl-N-formylanthranilic acid methyl esters under the conditions of the Claisen condensation.

  DOI：

  10.1007/s10593-008-0046-0

文献信息

• JP2002145838A
  申请人：——

  公开号：JP2002145838A

  公开（公告）日：2002-05-22
• [EN] METHODS FOR THE INHIBITION OF EGG PRODUCTION IN TREMATODES<br/>[FR] PROCEDE D'INHIBITION DE LA PRODUCTION D'OEUFS CHEZ LES TREMATODES
  申请人：UNIV CALIFORNIA

  公开号：WO2002005821A1

  公开（公告）日：2002-01-24

  The present invention comprises methods and compositions for use in inhibiting egg production by parasitic trematode worms comprising administering to an individual in need thereof an effective amount of an agent which transiently inhibits the influx of calcium through a cell membrane calcium channel. Inhibition of egg production in the worms ameliorates many of the symptoms and pathology related to infection by trematode related diseases, including Schistosomiasis. The methods can also effect disease transmission by reducing the number of eggs released into the environment available to continue the worm life cycle.
• Investigations of 2,3′-biquinolines 23. Synthesis of 1′-R-1′,4′-dihydro-2,3′-biquinolin-4′-ones by Claisen condensation
  作者：T. P. Glushenko、V. I. Goncharov、A. V. Aksenov

  DOI：10.1007/s10593-008-0046-0

  日期：2008.3

  A method has been developed for the synthesis of 1'-R-1',4'-dihydro-2,3'-biquinolin-4'-ones based on the interaction of quinaldine with N-alkyl-N-formylanthranilic acid methyl esters under the conditions of the Claisen condensation.