2-Amino-5-(methylamino)pentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-5-(methylamino)pentanoic acid
• 化学式: C₆H₁₄N₂O₂
• mdl: MFCD19206138
• 分子量: 146.19
• InChiKey: HZVXTZMGAFEVFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] KAPPA OPIOID RECEPTOR PEPTIDE AMIDE AGONISTS<br/>[FR] AGONISTES AMIDES PEPTIDIQUES DU RÉCEPTEUR OPIOÏDE KAPPA
  申请人：HUMANWELL PHARMACEUTICAL US

  公开号：WO2021026492A1

  公开（公告）日：2021-02-11

  The present invention provides kappa opioid receptor peptide agonists, methods for preparing these compounds, compositions comprising these kappa opioid receptor peptide agonists, and methods of using the kappa opioid receptor peptide agonists to treat pain or other conditions.

  本发明提供了kappa阿片受体肽激动剂，制备这些化合物的方法，包含这些kappa阿片受体肽激动剂的组合物，以及使用这些kappa阿片受体肽激动剂来治疗疼痛或其他疾病的方法。
• Directed evolution of arginine deiminase for increased activity at physiological pH
  申请人：RWTH Aachen University

  公开号：EP2295560A1

  公开（公告）日：2011-03-16

  The present invention relates to modified arginine deiminases exhibiting an increased activity at a higher pH, compared to a non-modified arginine deiminase, as well as uses of these enzymes for the treatment of cancer and unwanted tumor-induced neovascularization in a cancer. The present invention further relates to a method for modifying the pH optimum of the activity of an arginine deiminase, wherein said modifying provides an increased activity of said modified arginine deiminase at a higher pH, compared to a non-modified arginine deiminase.

  本发明涉及经修饰的精氨酸脱亚胺酶，与未经修饰的精氨酸脱亚胺酶相比，经修饰的精氨酸脱亚胺酶在较高的pH值下表现出更高的活性，本发明还涉及这些酶在治疗癌症和不必要的肿瘤诱导的癌症新生血管中的用途。本发明进一步涉及一种改变精氨酸脱亚胺酶活性的最佳pH值的方法，其中所述改变使所述经修饰的精氨酸脱亚胺酶在较高pH值下的活性比未经修饰的精氨酸脱亚胺酶更高。
• AMINO ACID DERIVATIVES AND THEIR USE AS A SAG CONTROL AGENT
  申请人：Nuplex Resins B.V.

  公开号：EP1641888B1

  公开（公告）日：2012-02-29
• KAPPA OPIOID RECEPTOR PEPTIDE AMIDE AGONISTS
  申请人：Humanwell Pharmaceutical US

  公开号：US20210040150A1

  公开（公告）日：2021-02-11

  The present invention provides kappa opioid receptor peptide agonists, methods for preparing these compounds, compositions comprising these kappa opioid receptor peptide agonists, and methods of using the kappa opioid receptor peptide agonists to treat pain or other conditions.
• Means and Methods for Treating Bacterial Infections
  申请人：VIB VZW

  公开号：US20210077563A1

  公开（公告）日：2021-03-18

  The present invention relates to non-naturally occurring anti-bacterial peptides. More specifically the peptides can be used to treat multi-drug resistant bacterial infections. In addition, the present invention provides methods for producing anti-bacterial peptides.