ACC-9369 hydrochloride | 286380-57-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: ACC-9369 hydrochloride
• 英文别名: ethyl 3-[2-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]propanoate;hydrochloride
• CAS: 286380-57-2
• 化学式: C17H28ClNO4
• 分子量: 345.9
• InChiKey: IKFUEAAUZIWSDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.34
• 重原子数：
  23
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  67.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] CONTROLLING HEART RATE OR BLOOD PRESSURE IN PATIENTS CO-MEDICATED WITH PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF IMPOTENCE<br/>[FR] REGULATION DE LA FREQUENCE CARDIAQUE OU DE LA PRESSION ARTERIELLE CHEZ DES PATIENTS SOUS MEDICATION CONJOINTE D'INHIBITEURS DE LA PHOSPHODIESTERASE POUR UN TRAITEMENT DE L'IMPUISSANCE
  申请人：SELECTUS PHARMACEUTICALS INC

  公开号：WO2000043012A1

  公开（公告）日：2000-07-27

  The present invention provides a method for attenuating acute onset of heart rate or blood pressure increase in patients where the use of nitrate-containing drugs is contraindicated. Specifically disclosed are a method and a combination therapy for the control of heart rate or blood pressure during short term activities following administration of drugs such as sildenafil for treatment of impotence. The method comprises administration of beta-blockers, preferably rapid-acting beta blockers, such as (S)-(-)-ethyl 3-[2-[2-hydroxy-3-(isopropylamino) propoxy]phenyl]propionate hydrochloride at the onset of symptoms, at a pre-determined time before or following administration of sildenafil, or concomitantly with sildenafil or similar-acting anti-impotence agents.