Etrogol | 119417-97-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Etrogol
• 英文别名: 2-[4-(3-methylbut-2-enoxy)phenyl]ethanol
• CAS: 119417-97-9
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: IBVFUNAQXWFZQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Etrogol 在 sodium periodate 、 溶剂黄146 、 lithium bromide 、 甲醇 、 potassium carbonate 作用下， 反应 23.0h， 以15%的产率得到4-(2',3'-dihydroxy-3'-methylbutanoxy)phenethanol
  参考文献：
  名称：

  反对从红树林Avicennia marina 中分离的天然苯乙醇的结构的证据

  摘要：

  摘要为了建立先前报道的天然三醇的绝对构型，以对映体富集的形式合成了所提出的结构。合成样品的 NMR 和比旋光度与文献中报道的完全不相容，因此反驳了先前指定的结构。图形概要

  DOI：

  10.1080/00397911.2016.1198813
• 作为产物：
  描述：

  对羟基苯乙酸 在 sodium tetrahydroborate 、 碘 、 potassium carbonate 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 6.0h， 生成 Etrogol
  参考文献：
  名称：

  Venkateswarlu, Somepalli; Panchagnula, Gopala K.; Subbaraju, Gottumukkala V., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 4, p. 1063 - 1066

  摘要：

  DOI：

文献信息

• [EN] SKIN PIGMENTATION MODIFIERS TO DARKEN OR LIGHTEN THE SKIN<br/>[FR] AGENTS DE MODIFICATION DE LA PIGMENTATION DE LA PEAU EN VUE DE L'ASSOMBRIR OU DE L'ÉCLAIRCIR
  申请人：AFFICHEM

  公开号：WO2016193220A1

  公开（公告）日：2016-12-08

  The present invention relates to a method for changing the pigmentation of a skin, a mucous membrane or hair with a compound of general formula (I), a cosmetic use of said compound of general formula (I), to cosmetic compositions comprising said compound of general formula (I), and to new depigmenting agents.

  本发明涉及一种改变皮肤、粘膜或头发色素的方法，使用一般式(I)的化合物，以及所述一般式(I)的化合物的化妆用途，包括所述一般式(I)的化合物的化妆组合物，以及新的脱色剂。
• DEPIGMENTING AGENTS TO LIGHTEN THE SKIN
  申请人：Affichem

  公开号：EP3097904A1

  公开（公告）日：2016-11-30

  The present invention relates to a method for lightening a skin or a mucous membrane with a depigmenting agent, a cosmetic use of said depigmenting agent, to cosmetic compositions comprising said agent, and to new depigmenting agents.

  本发明涉及一种使用脱色剂淡化皮肤或粘膜的方法、所述脱色剂的化妆品用途、包含所述脱色剂的化妆品组合物以及新型脱色剂。
• Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist
  作者：Francesco Epifano、Salvatore Genovese、E. James Squires、Matthew A. Gray

  DOI：10.1016/j.bmcl.2012.03.057

  日期：2012.5

  A series of 29 oxyprenylated and azoprenylated phenylpropanoids were chemically synthesized and tested in transfected cultured HepG2 cells by means of the dual-luciferase assay as farnesoid X receptor (FXR) agonists, using the endogenous ligand chenodeoxycholic acid (CDCA) as reference drug. Among the tested molecules, three compounds, namely auraptene, nelumol A, and nelumal A showed a potency comparable to the endogenous ligand, with the latter natural product having a level of activity slightly superior to CDCA. Nelumal A is thus of interest as a valuable potential novel lead compound in the search for FXR agonists. (C) 2012 Elsevier Ltd. All rights reserved.
• A Novel 5-HT Receptor Ligand and Related Cytotoxic Compounds from an Acid Mine Waste Extremophile
  作者：Andrea A. Stierle、Donald B. Stierle、Eric Goldstein、Keith Parker、Tim Bugni、Chad Baarson、Julie Gress、Danielle Blake

  DOI：10.1021/np030044w

  日期：2003.8.1

  Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich in toxic metals. A Pithomyces sp. isolated from the Pit Lake yielded three tyrosine derivatives (1-3), one of which acts as a 5-HT(2a) receptor ligand. This type of activity has been associated with migraine preventative and antihypertensive drugs. The isolation and characterization of compounds 1-3 and three sesquiterpenes (5-7) that have been isolated previously from higher plants are reported here.
• Venkateswarlu, Somepalli; Panchagnula, Gopala K.; Subbaraju, Gottumukkala V., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 4, p. 1063 - 1066
  作者：Venkateswarlu, Somepalli、Panchagnula, Gopala K.、Subbaraju, Gottumukkala V.

  DOI：——

  日期：——