2-(Dihydroxyamino)-3-phenylpropanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(Dihydroxyamino)-3-phenylpropanoic acid
• 化学式: C₉H₁₁NO₄
• 分子量: 197.19
• InChiKey: IDBRDXGJPFCEFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  81
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] MULTIFUNCTIONAL MEMBRANE-ACTIVE AMINOGLYCOSIDE-PEPTIDE CONJUGATES<br/>[FR] CONJUGUÉS AMINOGLYCOSIDE-PEPTIDE MULTIFONCTIONNELS À ACTIVITÉ MEMBRANAIRE
  申请人：UNIV CALIFORNIA

  公开号：WO2016025627A1

  公开（公告）日：2016-02-18

  Compositions and methods are disclosed that relate to aminoglycoside-linker-peptide (P-L-A) conjugates having unexpectedly advantageous dual-function bactericidal properties. Encompassed compounds are shown to be capable of energy independent bacterial plasma membrane disruption and to exhibit potent toxicity to bacteria including antibiotic-resistant bacteria. These and related embodiments will find uses for treating bacterial infections including overcoming antibiotic resistance.

  揭示了与氨基糖苷-连接肽（P-L-A）共轭物相关的具有意外优势双重杀菌性能的组合物和方法。所涵盖的化合物被证明能够独立于能量的细菌质膜破坏，并对包括抗生素耐药细菌在内的细菌表现出强大的毒性。这些及相关实施例将用于治疗细菌感染，包括克服抗生素耐药性。
• Coordination complexes for detecting analytes, and methods of making and using the same
  申请人：——

  公开号：US20030068275A1

  公开（公告）日：2003-04-10

  The present invention is directed, in part, to coordination complexes for detecting analytes, and methods of making and using the same.

  本发明部分涉及用于检测分析物的配位络合物，以及制备和使用该配位络合物的方法。
• Methods for treating autoimmune disorders, and reagents related thereto
  申请人：Bachovchin W. William

  公开号：US20050070459A1

  公开（公告）日：2005-03-31

  The invention generally relates to improved methods for treatment or prophylaxis in animal subjects (including humans) of autoimmune disorders including Type I diabetes, septic shock, multiple sclerosis, inflammatory bowel disease (IBD) and Crohn's disease.

  这项发明通常涉及改进的方法，用于治疗或预防动物主体（包括人类）的自身免疫性疾病，包括I型糖尿病、感染性休克、多发性硬化、炎症性肠病（IBD）和克罗恩病。
• POLYMER PRECURSORS OF RADIOLABELED COMPOUNDS, AND METHODS OF MAKING AND USING THE SAME
  申请人：University of Western Ontario

  公开号：US20150239797A1

  公开（公告）日：2015-08-27

  One aspect of the present invention relates to novel compounds that can be used to prepare radiolabeled compounds in an effective manner. A second aspect of the present invention relates to a method of synthesizing radiolabeled compounds.

  本发明的一个方面涉及可以用于有效制备放射标记化合物的新化合物。本发明的第二个方面涉及一种合成放射标记化合物的方法。
• Polymer precursors of radiolabeled compounds, and methods of making and using the same
  申请人：——

  公开号：US20020182169A1

  公开（公告）日：2002-12-05

  One aspect of the present invention relates to novel compounds that can be used to prepare radiolabeled compounds in an effective manner. A second aspect of the present invention relates to a method of synthesizing radiolabeled compounds.

  本发明的一个方面涉及可以有效地用于制备放射标记化合物的新化合物。本发明的第二个方面涉及一种合成放射标记化合物的方法。