3-(Hydroxy-methyl)-pentanedioic acid | 121152-92-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(Hydroxy-methyl)-pentanedioic acid
• 英文别名: 3-(hydroxymethyl)pentanedioic acid
• CAS: 121152-92-9
• 化学式: C₆H₁₀O₅
• 分子量: 162.14
• InChiKey: IEPDKRIDROAXQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• METHOD AND REAGENT FOR DETERMINING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL-COENZYME A AND COENZYME A
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP2380989A1

  公开（公告）日：2011-10-26

  The present invention provides a method for measuring the concentration of an analyte in a test solution wherein the analyte is mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A, comprising the following steps (p) and (q): (p) a step of allowing an enzyme that catalyzes a reaction represented by Reaction Formula 1 and an enzyme that catalyzes a reaction represented by Reaction Formula 2 to act on a test solution containing mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A in the presence of a hydrogen acceptor X, a hydrogen donor Y, and coenzyme A; and (q) a step of measuring an amount of: a reduced hydrogen acceptor X that is produced; or an oxidized hydrogen donor Y that is produced; or a hydrogen acceptor X that is decreased; or a hydrogen donor Y that is decreased, wherein the hydrogen donor Y and the reduced hydrogen acceptor X are not the same.

  本发明提供了一种测量试液中分析物浓度的方法，其中分析物为甲羟戊酸和/或3-羟甲基戊二酰辅酶A，该方法包括以下步骤(p)和(q)：(p) 让催化反应式 1 所代表的反应的酶和催化反应式 2 所代表的反应的酶在氢受体 X、氢供体 Y 和辅酶 A 的存在下作用于含有甲羟戊酸和/或 3-羟甲基戊二酰辅酶 A 的试液的步骤；和 (q) 测量以下物质的量的步骤：产生的还原氢受体 X；或产生的氧化氢供体 Y；或减少的氢受体 X；或减少的氢供体 Y，其中氢供体 Y 和还原氢受体 X 并不相同。
• Graphite electrode comprising electrochemically reduced graphene oxide and methods thereof
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US10156539B2

  公开（公告）日：2018-12-18

  A modified graphite electrode comprising a coating of electrochemically reduced graphene oxide. The modified graphite electrode may be employed in detecting of uric acid. A sensing device comprising the modified graphite electrode and a method of making the modified graphite electrode are described herein.

  一种改性石墨电极，包括一层电化学还原氧化石墨烯涂层。改性石墨电极可用于检测尿酸。本文描述了一种包含改性石墨电极的传感装置和一种制造改性石墨电极的方法。
• Method and reagent for measuring mevalonic acid, 3-hydroxymethylglutaryl coenzyme A, and coenzyme A
  申请人：ASAHI KASEI PHARMA CORPORATION

  公开号：US10975411B2

  公开（公告）日：2021-04-13

  The present invention provides a method for measuring the concentration of an analyte in a test solution wherein the analyte is mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A, comprising the following steps (p) and (q): (p) a step of allowing an enzyme that catalyzes a reaction represented by Reaction Formula 1 and an enzyme that catalyzes a reaction represented by Reaction Formula 2 to act on a test solution containing mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A in the presence of a hydrogen acceptor X, a hydrogen donor Y, and coenzyme A; and (q) a step of measuring an amount of: a reduced hydrogen acceptor X that is produced; or an oxidized hydrogen donor Y that is produced; or a hydrogen acceptor X that is decreased; or a hydrogen donor Y that is decreased, wherein the hydrogen donor Y and the reduced hydrogen acceptor X are not the same.

  本发明提供了一种测量试液中分析物浓度的方法，其中分析物为甲羟戊酸和/或3-羟甲基戊二酰辅酶A，该方法包括以下步骤(p)和(q)：(p) 让催化反应式 1 所代表的反应的酶和催化反应式 2 所代表的反应的酶在氢受体 X、氢供体 Y 和辅酶 A 的存在下作用于含有甲羟戊酸和/或 3-羟甲基戊二酰辅酶 A 的试液的步骤；和 (q) 测量以下物质的量的步骤：产生的还原氢受体 X；或产生的氧化氢供体 Y；或减少的氢受体 X；或减少的氢供体 Y，其中氢供体 Y 和还原氢受体 X 并不相同。
• Detection of serum methionine and glucose by graphite pencil electrode
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US11474067B2

  公开（公告）日：2022-10-18

  A method of using a graphite electrode to measure a concentration of glucose or methionine from a biological sample is described. A mechanical pencil lead may be used, as the graphite electrode, and the biological sample may come from a patient's serum. The glucose or methionine may produce a peak current response within a range of 0.4-0.8 V when the sample is subjected to linear scan voltammetry.

  描述了一种使用石墨电极测量生物样本中葡萄糖或蛋氨酸浓度的方法。可以使用机械铅笔芯作为石墨电极，生物样本可以来自病人的血清。在对样品进行线性扫描伏安法测量时，葡萄糖或蛋氨酸可在 0.4-0.8 V 范围内产生峰值电流响应。
• [EN] METHOD FOR PREPARING ROSUVASTATIN INTERMEDIATE<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN INTERMÉDIAIRE DE LA ROSUVASTATINE
  申请人：ENZYMEWORKS INC

  公开号：WO2014205917A1

  公开（公告）日：2014-12-31

  提供了罗素伐他汀中间体（R）-3-羟基戊二酸单甲酯和羟基被保护的（R）-3-羟基戊二酸单甲酯的制备方法，以（R）-4-氰基-3-羟基丁酸甲酯为底物，使其在酶的作用下反应生成所述（R）-3-羟基戊二酸单甲酯，所述的酶为重组腈水解酶，所述的反应在pH为7.0-9.0的水相缓冲液中以及温度25°C~35°C下进行。该方法反应条件温和，反应效率高，操作简便，并且通过采用特定的重组腈水解酶，解决了现有生物法中底物浓度过低，转化率低的问题。