Firibastat, (+/-)- | 721392-96-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: Firibastat, (+/-)-
• 英文别名: 3-amino-4-[(2-amino-4-sulfobutyl)disulfanyl]butane-1-sulfonic acid
• CAS: 721392-96-7
• 化学式: C₈H₂₀N₂O₆S₄
• 分子量: 368.5
• InChiKey: HJPXZXVKLGEMGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.9
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  228
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• [EN] CRYSTALLINE PHASE OF (3S.3S') 4,4'-DISULFANEDIYLBIS(3-AMINOBUTANE 1 -SULFONIC ACID) WITH L-LYSINE<br/>[FR] PHASE CRISTALLINE DE L'ACIDE (3S.3S') 4,4'-DISULFANEDIYLBIS(3-AMINOBUTANE 1-SULFONIQUE) AVEC LA L-LYSINE
  申请人：QUANTUM GENOMICS

  公开号：WO2014064077A1

  公开（公告）日：2014-05-01

  The present invention relates to a new crystalline phase of (3S,3S') 4,4'-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and its use, particularly in the pharmaceutical industry, and to processes for preparation thereof. The invention is also directed to pharmaceutical compositions containing at least one crystalline phase of (3S,3S') 4,4'-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and to the therapeutic or prophylactic use of such crystalline phase and compositions comprising the same.

  本发明涉及一种新的结晶相，即（3S,3S'）4,4'-二硫代双(3-氨基丁烷-1-磺酸)（ABSD）与L-赖氨酸的结晶相，特别是在制药行业中的用途，以及其制备方法。该发明还涉及含有至少一种（3S,3S'）4,4'-二硫代双(3-氨基丁烷-1-磺酸)（ABSD）与L-赖氨酸的结晶相的药物组合物，以及该结晶相和含有该结晶相的组合物的治疗或预防用途。
• Method for the preparation of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid)
  申请人：Quantum Genomics

  公开号：EP2439192A1

  公开（公告）日：2012-04-11

  The present invention relates to a new method for the preparation of (3S,3S') 4,4'-disulfanediylbis(3-aminobutane 1-sulfonic acid) in five steps from (S)-ethyl 2-(benzyloxycarbonylamino)-4-(neopentyloxysulfonyl)butanoate A.

  本发明涉及一种从(S)-乙基2-(苄氧羰基氨基)-4-(新戊基氧磺酰基)丁酸酯A出发，经五步制备(3S,3S')-4,4'-二硫烷二基双(3-氨基丁烷-1-磺酸)的新方法。
• Novel derivatives of 4,4'-dithiobis-(3-aminobutane-1-sulfphonates) and compositions containing same
  申请人：Fournie-Zaluski Marie-Claude

  公开号：US20060135602A1

  公开（公告）日：2006-06-22

  The invention relates to the bis-hydrochloride of 4,4′-dithiobis-(3-aminobutane-1-sodium sulphonate) and the bis-trifluoracetate of 4,4′-dithiobis-(3-aminobutane-1-sulphonate of 2,2-dimethylpropyl). The invention also relates to a pharmaceutical composition comprising one of said compounds and to the use of one of said compounds for the production of a medicament. The invention is suitable for use in a treatment method for hypertension and indirectly- or directly-linked illnesses.

  该发明涉及4,4'-二硫双-(3-氨基丁烷-1-磺酸钠)的双盐酸盐和4,4'-二硫双-(3-氨基丁烷-1-磺酸氟乙酸酯)的双三氟乙酸盐。该发明还涉及包含上述化合物之一的药物组合物，以及使用上述化合物之一生产药物的用途。该发明适用于治疗高血压及间接或直接相关疾病的治疗方法。
• Novel derivatives of 4,4' dithiobis-(3-aminobutane-1-1-sulfonates) and compositions comprising the same
  申请人：Roques Pierre Bernard

  公开号：US20060205695A1

  公开（公告）日：2006-09-14

  The invention relates to derivatives of 4,4′-dithiobis-(3-aminobutane-1-sulfonates) of formula (1), of use for the treatment and prevention of primary and secondary arterial hypertension.

  本发明涉及公式（1）的4,4'-二硫基双(3-氨基丁烷-1-磺酸酯)的衍生物，用于治疗和预防原发性和继发性动脉高血压。
• METHOD FOR THE PREPARATION OF (3S, 3S') 4,4'-DISULFANEDIYLBIS (3-AMINOBUTANE 1-SULFONIC ACID)
  申请人：Balavoine Fabrice

  公开号：US20130231500A1

  公开（公告）日：2013-09-05

  The present invention relates to a new method for the preparation of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) in five steps from (S)-ethyl 2-(benzyloxycarbonylamino)-4-(neopentyloxysulfonyl)butanoate A.

  本发明涉及一种从（S）-乙基2-（苄氧羰基氨基）-4-（新戊氧基磺酰基）丁酸酯A经过五步制备（3S，3S'）4,4'-二硫醇基双（3-氨基丁烷-1-磺酸）的新方法。