calyxamine B

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: calyxamine B
• 英文别名: 1-(2,2,6,6-tetramethylpiperidin-4-ylidene)propan-2-one
• 化学式: C₁₂H₂₁NO
• 分子量: 195.305
• InChiKey: IIIRMHBNGRZGTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-propanimine 、 丙酮 在 乙二胺 作用下， 以 neat (no solvent) 为溶剂， 反应 48.0h， 以2%的产率得到四甲基哌啶酮
  参考文献：
  名称：

  Two-step synthesis and biological evaluation of calyxamines A and B

  摘要：

  A two-step synthesis of naturally occurring alkaloids calyxamines A and B featuring a tandem Mannichaldol condensation reaction under solvent free conditions, and their inhibitory activity against acetylcholinesterase (AChE) is reported. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.10.022

文献信息

• Substituted polyaminotriazines and the method of their preparation
  申请人：SLOVENSKA AKADEMIA VIED

  公开号：EP0377324A2

  公开（公告）日：1990-07-11

  Polyaminotriazines of the formula applicable as light stabilizers in which R¹ and R², either the same or different, stand for hydrogen 2,2,6,6 - tetramethyl - 4 - piperidyl group, or 1,2.2, 6,6 - pentamethyl - 4 - piperidyl group; R³ and R⁴stand for 1 - methyl - 2 - (2,2,6,6 - tetramethyl - 4 - piperidyl) ethyl group or its 1,2,2,6,6 - pentamethyl analogue, or R³ = H; Z¹ and Z² , either the same or different, stand for the groups; 2,2,6,6 - tetramethyl - 4 - piperidyl amino-, 1 - methyl - 2 - (2,2,6,6 - tetramethyl - 4 - piperidyl) ethylamino-, C₁ - C₁₈ alkyl amino- , di(C₁ - C₄ alkyl) amino-, cyclohexylamino-, dicyclohexyl amino, N(C₁ - C₄ alkyl) cyclohexylamino-, or morpholino-. The group X = Cl, Y = H ; X and Y are also groups of the reaction component used in the excess. The molecular weight Mn varies between 1500 and 12000; m=1-10, n=1-8, p=1-5. The method of preparation of polyaminotriazines of the above formula is based upon the successive condensation of 2,4 - dichloro - s - triazine (containing 5 wt.% at maximum of cyanuric chloride) occurring via the substituents Z¹ and Z² in position 6 with diamines HN(R¹) (CH₂)₆NH(R²) and HN(R³) (CH₂)₆NH(R⁴) used either in excess or in deficit from 1 to 25 mol. %. The reaction is carried out at the temperatures from 70 to 210°C in an inert organic solvent and in the presence of inorganic base under opto ional addition of amino compound such as C₁- C₁₈alkyl amine, cyclohexyl amine, morpholine and 2,2,6,6 - tetramethyl - 4 - aminopiperidine.

  可用作光稳定剂的式中聚氨基三嗪 其中 R¹ 和 R²，可以相同或不同，代表 2，2，6，6-四甲基-4-哌啶基氢，或 1，2.R³和R⁴代表1-甲基-2-（2,2,6,6-四甲基-4-哌啶基）乙基或其1,2,2,6,6-五甲基类似物，或R³=H；Z¹和Z²，相同或不同，代表基团；2,2,6,6-四甲基-4-哌啶基氨基-，1-甲基-2-（2,2,6,6-四甲基-4-哌啶基）乙基氨基-，C₁ - C₁₈烷基氨基-、二(C₁ - C₄ 烷基)氨基-、环己基氨基-、二环己基氨基、N(C₁ - C₄ 烷基)环己基氨基-或吗啉基。基团 X = Cl，Y = H；X 和 Y 也是过量使用的反应组分的基团。分子量 Mn 在 1500 和 12000 之间；m=1-10，n=1-8，p=1-5。 上式的聚氨基三嗪的制备方法是将 2，4-二氯-s-三嗪（含 5 wt.在第 6 位的取代基 Z¹ 和 Z² 与二胺 HN(R¹) (CH₂)₆NH(R²) 和 HN(R³) (CH₂)₆NH(R⁴) 发生连续缩合。反应在 70 至 210°C 的温度下，在惰性有机溶剂和无机碱存在下进行，可选择加入氨基化合物，如 C₁-C₁₈烷基胺、环己基胺、吗啉和 2,2,6,6 - 四甲基 - 4 - 氨基哌啶。
• Two-step synthesis and biological evaluation of calyxamines A and B
  作者：Rosa-L. Meza-León、Alvaro Dávila-García、Fernando Sartillo-Piscil、Leticia Quintero、Martha Sosa Rivadeneyra、Silvano Cruz-Gregorio

  DOI：10.1016/j.tetlet.2013.10.022

  日期：2013.12

  A two-step synthesis of naturally occurring alkaloids calyxamines A and B featuring a tandem Mannichaldol condensation reaction under solvent free conditions, and their inhibitory activity against acetylcholinesterase (AChE) is reported. (C) 2013 Elsevier Ltd. All rights reserved.