Tetrafibricin | 151705-56-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Tetrafibricin
• 英文别名: (2E,4E,6E,8E,20E,30E,34E)-40-amino-11,15,17,19,23,25,27,29,33,37-decahydroxy-12-methyl-13-oxotetraconta-2,4,6,8,20,30,34-heptaenoic acid
• CAS: 151705-56-5
• 化学式: C₄₁H₆₇NO₁₃
• 分子量: 781.982
• InChiKey: BIOWDMWPQOMXJO-YHYSRAEPSA-N

物化性质

• 沸点：
  1024.7±65.0 °C(Predicted)
• 密度：
  1.230±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  55
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  283
• 氢给体数：
  12
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  Tetrafibricin 在 sodium tetrahydroborate 作用下， 以 水 为溶剂， 反应 1.0h， 生成 dihydrotetrafibricin
  参考文献：
  名称：

  Tetrafibricin, a novel fibrinogen receptor antagonist. II. Structural elucidation.

  摘要：

  The structure of tetrafibricin, a novel and potent fibrinogen receptor antagonist isolated from the culture broth of Streptomyces neyagawaensis NR0577, was determined. Tetrafibricin has a unique structure containing primary amine, conjugated tetraenoic acid, and polyhydroxy functionalities that is biosynthetically related to the polyene macrolide antibiotics.

  DOI：

  10.7164/antibiotics.46.1047

文献信息

• Tetrafibricin, a novel fibrinogen receptor antagonist. II. Structural elucidation.
  作者：TSUTOMU KAMIYAMA、YOSHIKO ITEZONO、TAKAYUKI UMINO、TOMOKO SATOH、NOBORU NAKAYAMA、KAZUTERU YOKOSE

  DOI：10.7164/antibiotics.46.1047

  日期：——

  The structure of tetrafibricin, a novel and potent fibrinogen receptor antagonist isolated from the culture broth of Streptomyces neyagawaensis NR0577, was determined. Tetrafibricin has a unique structure containing primary amine, conjugated tetraenoic acid, and polyhydroxy functionalities that is biosynthetically related to the polyene macrolide antibiotics.