2-[(2-Azaniumyl-3-hydroxybutanoyl)amino]-3-phenylpropanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(2-Azaniumyl-3-hydroxybutanoyl)amino]-3-phenylpropanoate
• 化学式: C13H18N2O4
• 分子量: 266.29
• InChiKey: IQHUITKNHOKGFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Detoxification of microbial virulence factors in oral cavity
  申请人：The Procter & Gamble Company

  公开号：US10156566B2

  公开（公告）日：2018-12-18

  A method for identifying constituents for detoxifying oral virulence factors and a method for determining the effectiveness of detoxifying agents.

  一种确定口腔致病因子解毒成分的方法和一种确定解毒剂有效性的方法。
• Probiotic treatment of skin diseases, disorders, and infections: formulations, methods and systems
  申请人：Baum Marc M.

  公开号：US10238597B2

  公开（公告）日：2019-03-26

  The present invention teaches compositions, methods and kits for treating skin conditions, including dandruff. In various embodiments, the compositions include an effective amount of one or more probiotic microorganism of vaginal origin and/or a fraction thereof and/or a component of the metabolome for preventing and/or treating skin disorders of the scalp.

  本发明教导用于治疗包括头皮屑在内的皮肤病的组合物、方法和试剂盒。在各种实施方案中，组合物包括有效量的一种或多种阴道源益生菌微生物和/或其组分和/或代谢组成分，用于预防和/或治疗头皮的皮肤疾病。
• Blood based biomarkers for diagnosing atherosclerotic coronary artery disease
  申请人：Global Genomics Group, LLC

  公开号：US10254272B2

  公开（公告）日：2019-04-09

  The invention, in some aspects, relates to methods for evaluating a human subject for having atherosclerotic coronary artery disease (ASCAD) or as having a coronary atherosclerotic plaque. In some aspects, the invention relates to methods and kits useful for diagnosing, classifying, profiling and treating atherosclerotic CAD and or a coronary atherosclerotic plaque.

  在某些方面，本发明涉及评估人体是否患有冠状动脉粥样硬化性疾病（ASCAD）或冠状动脉粥样硬化斑块的方法。在某些方面，本发明涉及用于诊断、分类、剖析和治疗动脉粥样硬化性冠状动脉疾病和或冠状动脉粥样硬化斑块的方法和试剂盒。
• Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment
  申请人：Metabolon, Inc.

  公开号：US10267777B2

  公开（公告）日：2019-04-23

  Methods are described herein for small molecule biochemical profiling of an individual subject for diagnosis of a disease or disorder, facilitating diagnosis of a disease or disorder, and/or identifying an increased risk of developing a disease or disorder in the individual subject. Aberrant levels of small molecules present in a sample from an individual subject are identified and diagnostic information relevant to the individual subject is obtained based on the identified aberrant levels. The obtained diagnostic information includes one or more of an identification of at least one biochemical pathway associated with the identified subset of the small molecules having aberrant levels, an identification at least one disease or disorder associated with the identified subset of the small molecules having aberrant levels, and an identification of at least one recommended follow up test associated with the identified subset of the small molecules having aberrant levels.

  本文描述了对个体受试者进行小分子生化分析的方法，以诊断疾病或失调，促进疾病或失调的诊断，和/或确定个体受试者罹患疾病或失调的风险增加。确定个体受试者样本中存在的小分子的异常水平，并根据确定的异常水平获得与个体受试者相关的诊断信息。所获得的诊断信息包括：至少一个生化途径的鉴定，该生化途径与所鉴定的具有异常水平的小分子子集相关；至少一种疾病或紊乱的鉴定，该疾病或紊乱与所鉴定的具有异常水平的小分子子集相关；至少一种推荐的后续检测的鉴定，该检测与所鉴定的具有异常水平的小分子子集相关。
• Detection of oral microbial virulence factors
  申请人：The Procter & Gamble Company

  公开号：US10267797B2

  公开（公告）日：2019-04-23

  Methods for detecting and quantifying toxins present in the oral cavity. The methods may include providing a biological sample, providing reporter cells expressing one or more Toll like receptors, exposing the cells to the biological sample, measuring the EC50 value of the lipopolysaccharide on activation of a Toll like receptor, quantification of the lipopolysaccharide in the biological sample.

  检测和量化口腔中毒素的方法。这些方法可包括提供生物样本，提供表达一种或多种类似 Toll 受体的报告细胞，将细胞暴露于生物样本，测量脂多糖激活类似 Toll 受体的 EC50 值，量化生物样本中的脂多糖。