1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine | 211512-92-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine
• 英文别名: 1-(Isopropylsulfonyl)-1H-benzo[d]imidazol-2-amine；1-propan-2-ylsulfonylbenzimidazol-2-amine
• CAS: 211512-92-4
• 化学式: C₁₀H₁₃N₃O₂S
• 分子量: 239.298
• InChiKey: RWKBNGLOXOXHLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  86.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine 在 盐酸 、 sodium hydroxide 、 tin(ll) chloride 、 sodium nitrite 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 3-{1-[1-(isopropylsulfonyl)-2-benzimidazolyl]hydrazino}propanenitrile
  参考文献：
  名称：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation

  摘要：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.

  DOI：

  10.1021/jm00117a010
• 作为产物：
  描述：

  2-氨基苯并咪唑 、 异丙基磺酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 生成 1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine
  参考文献：
  名称：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation

  摘要：

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.

  DOI：

  10.1021/jm00117a010

文献信息

• Design of Potent and Selective 2-Aminobenzimidazole-Based p38α MAP Kinase Inhibitors with Excellent in Vivo Efficacy
  作者：Alfonso de Dios、Chuan Shih、Beatriz López de Uralde、Concepción Sánchez、Miriam del Prado、Luisa M. Martín Cabrejas、Sehila Pleite、Jaime Blanco-Urgoiti、María José Lorite、C. Richard Nevill、Rosanne Bonjouklian、Jeremy York、Michal Vieth、Yong Wang、Nicholas Magnus、Robert M. Campbell、Bryan D. Anderson、Denis J. McCann、Deborah D. Giera、Paul A. Lee、Richard M. Schultz、Li、Lea M. Johnson、Jeffrey A. Wolos

  DOI：10.1021/jm048978k

  日期：2005.4.1

  We report the design and discovery of a 2-aminobenzimidazole-based series of potent and highly selective p38alphainhibitors. The lead compound 1 had low-nanomolar activity in both ATP competitive enzyme binding and inhibition of TNFalpha release in macrophages. Compound 18 showed excellent pharmacokinetics properties and oral activity in the rat collagen induced arthritis model compared with other

  我们报告了基于2-氨基苯并咪唑的有效和高度选择性的p38alphainhibitors系列的设计和发现。铅化合物1在ATP竞争性酶结合和巨噬细胞中的TNFα释放抑制方面均具有低纳摩尔活性。与其他p38参考化合物相比，化合物18在大鼠胶原蛋白诱发的关节炎模型中显示出出色的药代动力学特性和口服活性。还介绍了解决CyP3A4责任的SAR策略。
• Palladium-Catalyzed Hydroarylation of Propiolamides. A Regio- and Stereocontrolled Method for Preparing 3,3-Diarylacrylamides
  作者：Lynne A. Hay、Thomas M. Koenig、Francis O. Ginah、James D. Copp、David Mitchell

  DOI：10.1021/jo980235h

  日期：1998.7.1

  A general regio- and stereoselective synthesis of 3,3-diarylacrylamides is reported. Palladium-catalyzed coupling reactions of propiolamides with aryl halides provide arylpropiolamides. A subsequent hydroarylation reaction of these arylpropiolamides with aryl halides, catalytic palladium, an amine base, and formic acid in refluxing ethyl acetate provides 3,3-diarylacrylamides regio- and stereoselectively. The unique stereo- and regiocontrol is presumed to proceed through careful reaction parameters that allow intramolecular coordination of the propiolamide amide functionality to the transient palladium-alkyne complex. Palladium-catalyzed hydroarylation of propiolamides has not been studied; however, preliminary results from related systems suggest that regioselective addition can be achieved. The methodology as a synthesis tool is demonstrated in an efficient route to previously difficult-to-prepare potent, benzimidazole antiviral targets. In addition, the synthesis scope is explored where, by judicious choice of reaction sequence and aryl iodide, either the Z- or E-geometric isomer of a given pair of 3,3-diarylacrylamides is independently prepared.
• 3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation
  作者：Fortuna Haviv、James D. Ratajczyk、Robert W. DeNet、Francis A. Kerdesky、Roland L. Walters、Steven P. Schmidt、James H. Holms、Patrick R. Young、George W. Carter

  DOI：10.1021/jm00117a010

  日期：1988.9

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.
• Identification of 1-isopropylsulfonyl-2-amine benzimidazoles as a new class of inhibitors of hepatitis B virus
  作者：Yun-Fei Li、Gui-Feng Wang、Yu Luo、Wei-Gang Huang、Wei Tang、Chun-Lan Feng、Li-Ping Shi、Yu-Dan Ren、Jian-Ping Zuo、Wei Lu

  DOI：10.1016/j.ejmech.2007.03.005

  日期：2007.11

  A series of 1-isopropylsulfonyl-2-amine benzimidazole derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. In general, these derivatives are potent HBV inhibitors (IC50 < 4 mu M) with high selectivity indices (SIs > 40). Compounds 5b-e, g, j, and 9a were among the most prominent compounds, with IC(50)s of 0.70-2.0 mu M and SIs of 41-274. The potent anti-HBV activity and safety profiles of the most promising compounds 5d and j (IC(50)s = 0.70 mu M, SIs > 120) demonstrate the potential of this series of benzimidazoles for the development of new anti-HBV drugs. (C) 2007 Elsevier Masson SAS. All rights reserved.