calcium;3-hydroxy-3-methylbutanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: calcium;3-hydroxy-3-methylbutanoate
• 化学式: C10H18CaO6
• 分子量: 274.32
• InChiKey: WLJUMPWVUPNXMF-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.59
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Beta-HYDROXY-Beta-METHYLBUTYRIC ACID PURIFICATION METHOD
  申请人：TSI (CHINA) CO., LTD

  公开号：US20160052856A1

  公开（公告）日：2016-02-25

  The present invention relates to a method for purifying β-hydroxyl-β-methyl butyrate, comprising neutralizing a crude β-hydroxyl-β-methyl butyrate with a base to produce a salt of β-hydroxyl-β-methyl butyrate, cooling and crystallizing, dissolving and acidifying, and extracting to obtain β-hydroxyl-β-methyl butyrate of high purity. No strict conditions, such as high temperature and high vacuum, are required in this method. On the contrary, it has low requirement on the apparatus, the process can readily be controlled and a product with high purity can be produced.

  本发明涉及一种用于纯化β-羟基-β-甲基丁酸盐的方法，包括用碱中和粗β-羟基-β-甲基丁酸盐以产生β-羟基-β-甲基丁酸盐，冷却结晶，溶解酸化，提取以获得高纯度的β-羟基-β-甲基丁酸盐。该方法不需要严格的条件，如高温和高真空。相反，它对设备的要求低，过程可以轻松控制，并且可以生产高纯度的产品。
• [EN] PROCESS FOR MANUFACTURING HMB AND SALTS THEREOF<br/>[FR] PROCÉDÉ DE FABRICATION DE HMB ET DE SES SELS
  申请人：ABBOTT LAB

  公开号：WO2013025775A1

  公开（公告）日：2013-02-21

  A continuous process and system for manufacturing beta-hydroxy-beta-methylbutyrate (HMB) and salts thereof is provided. The continuous process includes providing at least one oxidant and diacetone alcohol, and combining the at least one oxidant with the diacetone alcohol in a first flow reactor to produce a product stream comprising HMB or a salt thereof. Optionally, the process includes a second flow reactor for the acidification of a salt of beta-hydroxy-beta-methylbutyrate to produce beta-hydroxy-beta-methylbutyrate in free acid form.

  提供了一种用于制造β-羟基-β-甲基丁酸（HMB）及其盐的连续工艺和系统。该连续工艺包括提供至少一种氧化剂和二丙酮醇，并将至少一种氧化剂与二丙酮醇在第一流动反应器中结合以产生包含HMB或其盐的产品流。可选地，该工艺包括第二流动反应器，用于酸化β-羟基-β-甲基丁酸盐以产生游离酸形式的β-羟基-β-甲基丁酸。
• Water-soluble polymers for the reduction of dietary phosphate or oxalate absorption
  申请人：——

  公开号：US20020064511A1

  公开（公告）日：2002-05-30

  The present invention is directed to a water-soluble polyether glycol polymer having: a structural backbone of carbon atoms and oxygen atoms where there are at least two consecutive carbon atoms present between each oxygen atom; a moiety on the backbone of the polymer or a functionalized derivative on the polymer, that is cationic at physiological pH and permits complexation with phosphate or oxalate; and an average molecular weight from about 5,000 to about 750,000 Daltons. These polymers are formulated for oral dosage to reduce the phosphonate or oxalate levels in an animal. The process of preparing these polymers and the method of reducing gastrointestinal absorption of phosphate and oxalate are included.

  本发明涉及一种水溶性聚醚聚醇聚合物，其具有以下特征：碳原子和氧原子构成的结构骨架，在每个氧原子之间至少存在两个相邻的碳原子；聚合物骨架上的基团或聚合物上的官能化衍生物，在生理pH下是阳离子的，并允许与磷酸盐或草酸盐形成配合物；平均分子量约为5,000至750,000道尔顿。这些聚合物被制成口服剂量形式，以降低动物体内的磷酸盐或草酸盐水平。本发明还包括制备这些聚合物的方法以及减少磷酸盐和草酸盐胃肠吸收的方法。
• Nutritional compositions including beta-hydroxy-beta-methylbutyrate for regulating transcription factors
  申请人：Abbott Laboratories, Inc.

  公开号：EP2647374A1

  公开（公告）日：2013-10-09

  Disclosed are nutritional compositions that include beta-hydroxy-beta-methylbutyrate. The nutritional compositions may be administered to prevent and/or reduce and/or treat diseases and conditions associated with downregulation of serine-threonine kinase protein kinase B (Akt/PKB) signaling pathways, with the concomitant FOXO transcription factors activation, such as muscle wasting, diabetes, infertility, neurodegeneration, and immune system dysfunction.

  本发明公开了包括β-羟基-β-甲基丁酸的营养组合物。这些营养组合物可用于预防和/或减少和/或治疗与丝氨酸-苏氨酸激酶蛋白激酶 B（Akt/PKB）信号通路下调以及伴随的 FOXO 转录因子激活有关的疾病和病症，如肌肉萎缩、糖尿病、不孕症、神经变性和免疫系统功能障碍。
• Antidepressant effect of ß-hydroxy-ß-methylbutyrate
  申请人：Abbott Laboratories, Inc.

  公开号：EP2745708A1

  公开（公告）日：2014-06-25

  A method of treating or preventing depression using β-hydroxy-β-methylbutyrate (HMB) is described. The method includes administering an effective amount of HMB or a pharmaceutically acceptable salt thereof to a subject in need thereof. The HMB can be administered as part of a nutritional composition. Also provided is a method of treating or preventing a condition which can be improved or prevented by the activation of mTOR signaling by administering an effective amount of HMB or a pharmaceutically acceptable salt thereof to a subject in need thereof.

  本文描述了一种使用β-羟基-β-甲基丁酸（HMB）治疗或预防抑郁症的方法。该方法包括向有需要的受试者施用有效量的 HMB 或其药学上可接受的盐。HMB 可作为营养组合物的一部分给药。还提供了一种治疗或预防病症的方法，通过向有需要的受试者施用有效量的 HMB 或其药学上可接受的盐，可通过激活 mTOR 信号转导改善或预防病症。

表征谱图