3-Hydroxy-2-[[3-hydroxy-2-methyl-2-(4-methylpent-3-enyl)-3,4-dihydrochromene-6-carbonyl]amino]butanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Hydroxy-2-[[3-hydroxy-2-methyl-2-(4-methylpent-3-enyl)-3,4-dihydrochromene-6-carbonyl]amino]butanoic acid
• 化学式: C₂₁H₂₉NO₆
• 分子量: 391.5
• InChiKey: JEQRSDJVWOFRBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• BIOSYNTHESIS GENE CLUSTER OF STREPTOMYCES XIAMENENSIS, PURPOSE, AND BACTERIAL STRAIN
  申请人：Shanghai Jiao Tong University

  公开号：EP3103873A1

  公开（公告）日：2016-12-14

  The present invention involves the application of a gene cluster, and bacterial strains that used in the biosynthesis of Xiamenmycin. The nucleotide sequence of the gene cluster is showed as SEQ ID NO.1, with the whole length of 5189 base pairs. The present invention involves Streptomyces xiamenensis CGMCC No. 5670 and its mutant strain, and the method that how the mentioned bacterial strain produces Xiamenmycin. The present invention provides the strain sources by using Streptomyces xiamenensis, its mutant strains or genetically engineered microbial strains carrying the above-mentioned Xiamenmycin biosynthesis gene cluster for cultivation and produce benzopyran compound Xiamenmycin through biosynthesis. The mutant strains can be used in industrial production.

  本发明涉及一种基因簇和用于厦门霉素生物合成的细菌菌株的应用。该基因簇的核苷酸序列如 SEQ ID NO.1 所示，全长 5189 碱基对。本发明涉及厦门链霉菌（Streptomyces xiamenensis）CGMCC No.5670及其突变菌株，以及所述菌株生产厦门霉素的方法。本发明提供菌株来源，利用厦门链霉菌及其突变菌株或携带上述厦门霉素生物合成基因簇的基因工程微生物菌株进行培养，通过生物合成生产苯并吡喃化合物厦门霉素。突变菌株可用于工业生产。
• BIOSYNTHESIS GENE CLUSTER OF STREPTOMYCES XIAMENENSIS, USE AND BACTERIAL STRAIN
  申请人：Shanghai Jiao Tong University

  公开号：EP3103873B1

  公开（公告）日：2018-07-11