1-((1S)-1-(4-Methoxyphenyl)-2-(methylamino)ethyl)cyclohexanol | 392332-59-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-((1S)-1-(4-Methoxyphenyl)-2-(methylamino)ethyl)cyclohexanol
• 英文别名: 1-[(1S)-1-(4-methoxyphenyl)-2-(methylamino)ethyl]cyclohexan-1-ol
• CAS: 392332-59-1
• 化学式: C₁₆H₂₅NO₂
• 分子量: 263.37
• InChiKey: MKAFOJAJJMUXLW-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

ADMET

代谢

N-去甲基文拉法辛是(s)-文拉法辛的人类已知代谢物。

N-Desmethylvenlafaxine is a known human metabolite of (s)-venlafaxine.

来源:NORMAN Suspect List Exchange

文献信息

• Extended release pharmaceutical dosage form
  申请人：Wyeth

  公开号：EP1523979A1

  公开（公告）日：2005-04-20

  This invention relates to novel extended release pharmaceutical dosage forms for orally delivering drugs to mammals, e.g., humans. More particularly, this invention concerns novel dosage forms of water soluble drugs such as venlafaxine, enantiomeric (R or S) forms of venlafaxine, metabolites of venlafaxine such as O-desmethyl venlafaxine (ODV) or enantiomeric (R or S) forms of said metabolites which dosage forms have an extended release profile when taken orally. This invention also provides processes for preparing such dosage forms and methods of using them.

  本发明涉及向哺乳动物（如人类）口服给药的新型缓释药物剂型。更具体地说，本发明涉及水溶性药物如文拉法辛、文拉法辛的对映体（R或S）形式、文拉法辛的代谢物如O-去甲基文拉法辛（ODV）或上述代谢物的对映体（R或S）形式的新型剂型，这些剂型在口服时具有缓释特性。本发明还提供了制备此类剂型的工艺和使用方法。
• Enantiomers of N-desmethyl venlafaxine
  申请人：American Home Products Corporation

  公开号：US20020035158A1

  公开（公告）日：2002-03-21

  The present invention provides enantiomers of N-Desmethyl venlafaxine, as well as their use in pharmaceutical compositions and medically useful treatments, particularly including central nervous system uses.

  本发明提供了 N-去甲基文拉法辛的对映体，以及它们在药物组合物和医学治疗中的用途，特别是包括中枢神经系统用途。
• EXTENDED RELEASE PHARMACEUTICAL DOSAGE FORM
  申请人：Wyeth

  公开号：EP1675575A2

  公开（公告）日：2006-07-05
• Enantiomers of N-Desmethyl venlafaxine
  申请人：Yardley P. John

  公开号：US20070117870A1

  公开（公告）日：2007-05-24

  The present invention provides enantiomers of N-Desmethyl venlafaxine, as well as their use in pharmaceutical compositions and medically useful treatments, particularly including central nervous system uses.
• [EN] ENANTIOMERS OF N-DESMETHYL VENLAFAXINE<br/>[FR] ENANTIOMERES DE N-DESMETHYL VENLAFAXINE
  申请人：AMERICAN HOME PROD

  公开号：WO2000076956A2

  公开（公告）日：2000-12-21

  The present invention provides enantiomers of N-Desmethyl venlafaxine, as well as their use in pharmaceutical compositions and medically useful treatments, particularly including central nervous system uses.