3-ethyl-3-methyl-N-(2-sulfanylethyl)pentanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-ethyl-3-methyl-N-(2-sulfanylethyl)pentanamide
• 化学式: C₁₀H₂₁NOS
• 分子量: 203.35
• InChiKey: JRDHTTRXCOHBKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  30.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Reducible polymers for nonviral gene delivery
  申请人：Bikram Malavosklish

  公开号：US20100204301A1

  公开（公告）日：2010-08-12

  Provided herein are biodegradable copolymers and nanoplex delivery systems comprising the same and a cargo molecule, such as a nucleic acid, a polynucleotide or other biomolecule. The biodegradable copolymers may comprise a reducible polymer linearly modified with lysine, such as a linear lysine-modified N,N′-cystamine bisacrylamide. The biodegradable copolymers also may be conjugated to a sequestering moiety, such as dietheylamine. The biodegradable copolymers also may comprise one or both of a targeting moiety and one or more moieties to facilitate endosomal escape. Also provided are methods for treating a pathophysiological condition and for increasing biocompatibility of a polymeric delivery system upon delivery to a subject using the biodegradable copolymers and nanoplexes.