Eicosanoic acid, 2-amino-3-hydroxy-2-(hydroxymethyl)-14-oxo-, (2S,3S)- | 175521-91-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Eicosanoic acid, 2-amino-3-hydroxy-2-(hydroxymethyl)-14-oxo-, (2S,3S)-
• 英文别名: 2-amino-3-hydroxy-2-(hydroxymethyl)-14-oxoicosanoic acid
• CAS: 175521-91-2
• 化学式: C₂₁H₄₁NO₅
• 分子量: 387.6
• InChiKey: JVVUMRUWQBAVNC-UHFFFAOYSA-N

物化性质

• 沸点：
  587.9±50.0 °C(Predicted)
• 密度：
  1.058±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  27
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• NOVEL COMPOUNDS
  申请人：AVANTI POLAR LIPIDS, INC.

  公开号：US20160024001A1

  公开（公告）日：2016-01-28

  Disclosed are compounds of the general formula I and II (as further defined herein) are useful in the production of inhibitors of sphingolipid synthesis the production of sphingolipids. Suitable sphingolipids, include, but not limited to, sphingosine and compounds incorporating sphingosine or that may use sphingosine as an intermediate or a starting material in their synthesis (including, but not limited to, sphingosine-1-P, ceramide, gangliosides and sphigomyelin). In one contemplated use, compounds of the general formula I and II are useful in the production of sphingosine. In another contemplated use, compounds of the general formula I and II are useful in the production of a sphingofugin. Methods of manufacturing each of the above compounds are also provided.

  本发明公开了一般式I和II（如下文所定义）的化合物，其在制备鞘脂合成抑制剂和鞘脂的生产中有用。适当的鞘脂包括但不限于神经酰胺和包含神经酰胺或可能在其合成中使用神经酰胺作为中间体或起始材料的化合物（包括但不限于神经酰胺-1-P，鞘醇胺，神经节苷脂和鞘磷脂）。在一种考虑中，一般式I和II的化合物在制备神经酰胺方面有用。在另一种考虑中，一般式I和II的化合物在制备神经酰胺素方面有用。还提供了制造上述每种化合物的方法。
• US20140275591A1
  申请人：——

  公开号：US20140275591A1

  公开（公告）日：2014-09-18
• US9403760B2
  申请人：——

  公开号：US9403760B2

  公开（公告）日：2016-08-02
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：AVANTI POLAR LIPIDS INC

  公开号：WO2014153147A1

  公开（公告）日：2014-09-25

  Disclosed are compounds of the general formula I and II (as further defined herein) are useful in the production of inhibitors of sphingolipid synthesis the production of sphingolipids. Suitable sphingolipids, include, but not limited to, sphingosine and compounds incorporating sphingosine or that may use sphingosine as an intermediate or a starting material in their synthesis (including, but not limited to, sphingosine-1-P, ceramide, gangliosides and sphigomyelin). In one contemplated use, compounds of the general formula I and II are useful in the production of sphingosine. In another contemplated use, compounds of the general formula I and II are useful in the production of a sphingofugin. Methods of manufacturing each of the above compounds are also provided.