WF11899A

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: WF11899A
• 英文别名: [5-[2-[3-(3-Amino-1-hydroxy-3-oxopropyl)-18-(hexadecanoylamino)-11,20,21,25-tetrahydroxy-15-(1-hydroxyethyl)-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-6-yl]-1,2-dihydroxyethyl]-2-hydroxyphenyl] hydrogen sulfate
• 化学式: C₅₁H₈₂N₈O₂₁S
• 分子量: 1175.32
• InChiKey: KAPLTEIQCKDUAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  81
• 可旋转键数：
  24
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  483
• 氢给体数：
  16
• 氢受体数：
  21

反应信息

• 作为反应物：
  描述：

  WF11899A 在 immobilized cycloaliphatic peptide acyltransferase from Streptomyces sp. 6907 strain 作用下， 以 aq. phosphate buffer 为溶剂， 反应 4.0h， 生成 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0
  参考文献：
  名称：

  IMMOBILIZED CYCLOALIPHATIC PEPTIDE ACYLTRANSFERASE AND PREPARATION METHOD AND USES THEREOF

  摘要：

  Disclosed in the present invention are an immobilized cycloaliphatic peptide acyltransferase and a preparation method and use thereof. The cycloaliphatic peptide acyltransferase is immobilized on a carrier; the cycloaliphatic peptide acyltransferase is derived from natural or artificial mutants or variants thereof, or can be obtained by introducing a foreign cyclic acyltransferase gene and transforming thereafter; the material of the carrier is selected from an inorganic carrier or a polypropylene resin carrier. Also disclosed in the present invention are the preparation method for the immobilized cycloaliphatic peptide acyltransferase and uses thereof.

  公开号：

  US20200149029A1

文献信息

• METHOD FOR ACYLATING A CYCLIC PEPTIDE
  申请人：DSM Sinochem Pharmaceuticals Netherlands B.V.

  公开号：US20170327540A1

  公开（公告）日：2017-11-16

  The present invention relates to a process for acylating cyclic peptides bearing an amino group and to the application of said process in the preparation of anidulafungin and micafungin.

  本发明涉及一种对带有氨基的环肽进行酰化的过程，以及该过程在制备阿尼杜拉峰和米卡杜拉峰中的应用。
• Method for acylating a cyclic peptide
  申请人：DSM Sinochem Pharmaceuticals Netherlands B.V.

  公开号：US10954272B2

  公开（公告）日：2021-03-23

  The present invention relates to a process for acylating cyclic peptides bearing an amino group and to the application of said process in the preparation of anidulafungin and micafungin.

  本发明涉及一种使带有氨基的环肽酰化的工艺，以及该工艺在制备阿尼芬灵和米卡芬灵中的应用。
• WF11899A, B and C, novel antifungal lipopeptides. I. Taxonomy, fermentation, isolation and physico-chemical properties.
  作者：TOSHIRO IWAMOTO、AKIHIKO FUJIE、KAZUTOSHI SAKAMOTO、YASUHISA TSURUMI、NOBUHARU SHIGEMATSU、MICHIO YAMASHITA、SEIJI HASHIMOTO、MASAKUNI OKUHARA、MASANOBU KOHSAKA

  DOI：10.7164/antibiotics.47.1084

  日期：——

  WF 11899A, B and C, novel antifungal lipopeptide antibiotics were isolated from the culture broth of Coleophoma empetri F-11899. These compounds belong to the echinocandin type of lipopeptides. Of these compounds, WF11899 A showed good solubility in water. These three antibiotics possess potent in vitro antifungal activities against Candida spp.
• High-Yield Peptide Antibiotics Producing Strain, Preparation Method and Use Thereof
  申请人：Chen Yi

  公开号：US20140162314A1

  公开（公告）日：2014-06-12

  High-yield antibiotics producing strain, preparation method and use thereof are provided in the present invention. The high-yield strain is a mutagenized strain derived from Colephoma empetri, and deposited in CGMCC with the accession number of CGMCC 4129. The preparation method comprises the following steps: (a) mixing a seed liquid of Colephoma empetri of Accession No. FERM BP-2635 with nitrosoguanidine to obtain a mixture a; (b) mixing said mixture a with a wall-breaking enzyme to obtain protoplasts; (c) regenerating said protoplasts to obtain single colonies; and (d) culturing said single colonies to obtain said mutagenized strain. The obtained strain has stable genetic and producing property, produces little impurities in fermentation, and is suitable for industrialization.
• US8911968B2
  申请人：——

  公开号：US8911968B2

  公开（公告）日：2014-12-16