2-[3-(Furan-2-yl)prop-2-enoyl]indene-1,3-dione | 40479-06-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-[3-(Furan-2-yl)prop-2-enoyl]indene-1,3-dione
• CAS: 40479-06-9
• 化学式: C₁₆H₁₀O₄
• 分子量: 266.253
• InChiKey: KDHIKSJDTLPCPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  64.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[3-(Furan-2-yl)prop-2-enoyl]indene-1,3-dione 、 尿素 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以69%的产率得到2-[6-(furan-2-yl)-2-oxo-5,6-dihydro-1H-pyrimidin-4-yl]indene-1,3-dione
  参考文献：
  名称：

  Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives

  摘要：

  A new group of pyrimidine derivatives of indane-1,3-dione were synthesized aiming at the synthesis of new compounds acting as analgesic, anti-inflammatory and antimicrobial activity in a single component. The title compounds (3a-l) were synthesized from chalcone derivatives of indane-1,3-dione (2a-l) through cyclization reaction with urea. The synthesized compounds were characterized by FT-IR, H-1 NMR, mass spectral data, elemental analysis and evaluated for anti-inflammatory, analgesic, antibacterial and antifungal activities. The most active compound 3e, was evaluated for its ulcerogenicity. Good anti-inflammatory property was observed for chlorophenyl substituted pyrimidine derivatives. It mainly binds with Pro 218 of 1CX2, and the ligand could have caused much conformational changes in the protein structure than other derivatives. It also exhibits good analgesic and antimicrobial agent in a single component. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.09.050
• 作为产物：
  描述：

  糠醛 、 2-乙基-1,3-氢化茚二酮 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 生成 2-[3-(Furan-2-yl)prop-2-enoyl]indene-1,3-dione
  参考文献：
  名称：

  Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives

  摘要：

  A new group of pyrimidine derivatives of indane-1,3-dione were synthesized aiming at the synthesis of new compounds acting as analgesic, anti-inflammatory and antimicrobial activity in a single component. The title compounds (3a-l) were synthesized from chalcone derivatives of indane-1,3-dione (2a-l) through cyclization reaction with urea. The synthesized compounds were characterized by FT-IR, H-1 NMR, mass spectral data, elemental analysis and evaluated for anti-inflammatory, analgesic, antibacterial and antifungal activities. The most active compound 3e, was evaluated for its ulcerogenicity. Good anti-inflammatory property was observed for chlorophenyl substituted pyrimidine derivatives. It mainly binds with Pro 218 of 1CX2, and the ligand could have caused much conformational changes in the protein structure than other derivatives. It also exhibits good analgesic and antimicrobial agent in a single component. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.09.050

文献信息

• Treating and/or preventing insulin-resistance related weight gain
  申请人：University of South Florida

  公开号：US10688063B2

  公开（公告）日：2020-06-23

  Provided herein are methods of preventing or reducing weight gain in a subject in need thereof by administering 2-acetylcyclopentane-1,3-dione (ACPD).

  本文提供了通过施用 2-乙酰基环戊烷-1,3-二酮（ACPD）来防止或减少有需要的受试者体重增加的方法。
• TREATING AN ATYPICAL PROTEIN KINASE C ENZYME ABNORMALITY
  申请人：UNIVERSITY OF SOUTH FLORIDA

  公开号：US20160175274A1

  公开（公告）日：2016-06-23

  Provided herein are compounds, compositions, pharmaceutical formulations, methods of treating and methods of using aPKC inhibitors for treating and/or preventing of aPKC abnormalities.
• TREATING AND/OR PREVENTING INSULIN-RESISTANCE RELATED WEIGHT GAIN
  申请人：Farese Robert Vito

  公开号：US20180028488A1

  公开（公告）日：2018-02-01

  Provided herein are methods of preventing or reducing weight gain in a subject in need thereof by administering 2-acetylcyclopentane-1,3-dione (ACPD).
• US9795584B2
  申请人：——

  公开号：US9795584B2

  公开（公告）日：2017-10-24
• Synthesis pharmacological evaluation and docking studies of pyrimidine derivatives
  作者：D. Giles、Karki Roopa、F.R. Sheeba、P.M. Gurubasavarajaswamy、Goli Divakar、Thomas Vidhya

  DOI：10.1016/j.ejmech.2012.09.050

  日期：2012.12

  A new group of pyrimidine derivatives of indane-1,3-dione were synthesized aiming at the synthesis of new compounds acting as analgesic, anti-inflammatory and antimicrobial activity in a single component. The title compounds (3a-l) were synthesized from chalcone derivatives of indane-1,3-dione (2a-l) through cyclization reaction with urea. The synthesized compounds were characterized by FT-IR, H-1 NMR, mass spectral data, elemental analysis and evaluated for anti-inflammatory, analgesic, antibacterial and antifungal activities. The most active compound 3e, was evaluated for its ulcerogenicity. Good anti-inflammatory property was observed for chlorophenyl substituted pyrimidine derivatives. It mainly binds with Pro 218 of 1CX2, and the ligand could have caused much conformational changes in the protein structure than other derivatives. It also exhibits good analgesic and antimicrobial agent in a single component. (C) 2012 Elsevier Masson SAS. All rights reserved.