1-{2-[(1-Carboxy-3-phenylpropyl)amino]propanoyl}-hexahydro-2H-cyclopenta[B]pyrrole-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-{2-[(1-Carboxy-3-phenylpropyl)amino]propanoyl}-hexahydro-2H-cyclopenta[B]pyrrole-2-carboxylic acid
• 英文别名: 1-[2-[(1-carboxy-3-phenylpropyl)amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid
• 化学式: C₂₁H₂₈N₂O₅
• 分子量: 388.5
• InChiKey: KEDYTOTWMPBSLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Selective cyclooxygenase-2 inhibitors and vasomodulator compounds for generalized pain and headache pain
  申请人：——

  公开号：US20020077328A1

  公开（公告）日：2002-06-20

  A therapeutic combination useful in the treatment, amelioration, prevention, or delay of pain comprising a high energy form of a selective cyclooxygenase-2 inhibitor, a vasomodulator, and a pharmaceutically acceptable excipient, carrier, or diluent, the cyclooxygenase-2 inhibitor and vasomodulator each being present in an amount effective to contribute to the treatment, prevention, ameloriation or delay of pain.

  一种用于治疗、改善、预防或延缓疼痛的治疗组合物，包括一种高能形式的选择性环氧合酶-2 抑制剂、一种血管调节剂和一种药学上可接受的赋形剂、载体或稀释剂，环氧合酶-2 抑制剂和血管调节剂各自的有效含量有助于治疗、预防、改善或延缓疼痛。
• FOLIC ACID – RAMIPRIL COMBINATION: CELL PROTECTIVE, NEUROPROTECTIVE AND RETINOPROTECTIVE OPHTALMOLIGIC COMPOSITIONS
  申请人：REKIK Raouf

  公开号：US20150133455A1

  公开（公告）日：2015-05-14

  The invention relates to a cellprotective, neuroprotective and retinoprotective composition. In an embodiment of the invention, said composition comprises (i) Ramipril or Ramiprilate and (ii) folic acid. The composition of the invention can be used, in particular, for the prevention of loss of vision, or even for improving visual acuity and visual field in normal subjects, as well as for treating ophthalmologic pathologies, in particular: glaucoma, diabetic retinopathy, age related macular degeneration, hereditary dystrophy of the retina, uveitis, ammetropia (myopia, presbyopia). This combination of active principles could also be used in general conditions for treating general pathologies (cancer . . . ).
• ANGIOTENSIN CONVERTING ENZYME INHIBITORS FOR TREATING OPTIC NEUROPATHY OR CONGENITAL OPTIC ATROPHY
  申请人：Rekik Raouf

  公开号：US20150174146A1

  公开（公告）日：2015-06-25

  The present invention relates to an ophthalmic composition comprising at least one angiotensin converting enzyme (ACE) inhibitor and a pharmaceutically acceptable vehicle for use as an ophthalmic neuroprotector in treating an optic neuropathy or congenital optic atrophy.
• SALBUTAMOL-CONTAINING OPHTHALMIC MEDICAMENT
  申请人：REKIK Raouf

  公开号：US20190160027A1

  公开（公告）日：2019-05-30

  The invention relates to a medicament, the active principle of which is Salbutamol. It can be applied to the prevention and/or treatment of eye diseases or disorders, especially of Ametropia (myopia, Presbyopia), hereditary dystrophies of the retina, glaucoma, cataract, Keratoconus, macular degeneration, diabetic retinopathy, orbital and ocular inflammation (optic neuritis, uveitis), vitreo retinal proliferation or fibrosis, conjunctivitis, dry eye and all the ophthalmic diseases or disorders including a decrease of visual function.
• BIOSENSING PLATFORM FOR DETECTING VIRAL INFECTIONS AND METHODS FOR SCREENING A MODULATOR OF VIRAL INFECTIONS AND PROTECTING THEREFROM
  申请人：PD BIOMEDICAL CO., LTD.

  公开号：US20220117936A1

  公开（公告）日：2022-04-21

  Provided is a method for screening a modulator of a viral infection by detecting an interaction of angiotensin converting enzyme 2 (ACE2) and a spike protein with a biosensing platform. Also provided is a compound of formula (I) as a modulator of a viral infection, where R, X, A, R 3 to R 5 , and m are as defined herein, and a method for protecting a subject from a viral infection by administering with the compound.