2-(3,5-Dimethoxy-4-propoxyphenyl)-1-methylethylamin | 501700-11-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3,5-Dimethoxy-4-propoxyphenyl)-1-methylethylamin
• 英文别名: 3,5-dimethoxy-4-propoxyamphetamine；1-(3,5-Dimethoxy-4-propoxyphenyl)propan-2-amine
• CAS: 501700-11-4
• 化学式: C₁₄H₂₃NO₃
• 分子量: 253.342
• InChiKey: KKMCHCCXGKYEKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  53.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,5-二甲氧基-4-丙氧基-苯甲醛 在 lithium aluminium tetrahydride 、 硫酸 、 溶剂黄146 、 正丁胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 2-(3,5-Dimethoxy-4-propoxyphenyl)-1-methylethylamin
  参考文献：
  名称：

  摘要：

  The synthesis and the spectroscopic data of 14 novel 4-substituted mescaline derivatives are reported. Starting from syringalclehyde (=4-hydroxy-3,5-dimethoxybenzaldehyde). several ethers were obtained from reaction with a series of corresponding saturated and unsaturated alkyl- and fluoroalkyl halides. Henry-reaction with MeNO2 or EtNO2 followed to afford the nitro-olefines, which were then reduced with AlH3 to the desire(d) 2-phenylethyl- and 1-methyl-2-phenylethylamine derivatives.

  DOI：

  10.1002/1522-2675(200209)85:9<3019::aid-hlca3019>3.0.co;2-4

文献信息

• Antiparkinsonian Action of Phenylisopropylamines
  申请人：Caron G. Marc

  公开号：US20070027208A1

  公开（公告）日：2007-02-01

  A method of treating a subject for Parkinson's disease comprises administering said subject a phenylisopropylamine in an amount effective to treat said Parkinson's disease. In some embodiments the method is used to treat at least a motor symptom of Parkinson's disease; in some embodiments the method is used to treat at least a non-motor symptom of Parkinson's disease.
• US8877802B2
  申请人：——

  公开号：US8877802B2

  公开（公告）日：2014-11-04