1-Propanaminium, N,N,N-trimethyl-2,3-bis[(1-oxotetradecyl)oxy]- | 72719-83-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-Propanaminium, N,N,N-trimethyl-2,3-bis[(1-oxotetradecyl)oxy]-
• 英文别名: 2,3-di(tetradecanoyloxy)propyl-trimethylazanium
• CAS: 72719-83-6
• 化学式: C34H68NO4+
• 分子量: 554.9
• InChiKey: IGKWQNBUDQUOJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.6
• 重原子数：
  39
• 可旋转键数：
  31
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Methods and compositions for the efficient delivery of therapeutic agents to cells and animals
  申请人：Rana M. Tariq

  公开号：US20070260055A1

  公开（公告）日：2007-11-08

  The present invention provides methods of carrying out the safe and reliable preparation of lipids comprising quaternary amines. Such lipids are especially suited for introducing therapeutic agents into cells or organisms. In particular, the lipids of the invention are suitable for the efficient transfer of gene therapy agents into mammalian cells or organisms in a cell type specific or tissue specific manner.

  本发明提供了一种安全可靠的制备含季铵盐脂质的方法。这种脂质特别适合将治疗剂介入细胞或生物体中。特别是，本发明的脂质适用于以细胞类型特异性或组织特异性的方式高效地将基因治疗剂转移到哺乳动物细胞或生物体中。
• COMPOSITIONS AND METHODS FOR DELIVERY OF DOUBLE-STRANDED RNA
  申请人：Cui Kunyuan

  公开号：US20070293449A1

  公开（公告）日：2007-12-20

  Pharmaceutical compositions and methods of use of a composition containing a double-stranded RNA (dsRNA), cationic lipids, non-cationic lipids, and lipophilic delivery-enhancing compounds.
• COMPOSITIONS AND METHODS FOR LIPID AND POLYPEPTIDE BASED siRNA INTRACELLULAR DELIVERY
  申请人：Cui Kunyuan

  公开号：US20070281900A1

  公开（公告）日：2007-12-06

  A composition of an interfering RNA comprising a double-stranded RNA (dsRNA) molecule having a double-stranded region of from about 15 to about 40 base pairs, a peptide having a hydrophobic region and a cationic region, and a non-cationic phospholipid, and uses thereof.
• US8329681B2
  申请人：——

  公开号：US8329681B2

  公开（公告）日：2012-12-11