1-[3-[(3-Azaniumyl-3-carboxylatopropyl)azaniumyl]-3-carboxylatopropyl]azetidin-1-ium-2-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[3-[(3-Azaniumyl-3-carboxylatopropyl)azaniumyl]-3-carboxylatopropyl]azetidin-1-ium-2-carboxylate
• 化学式: C₁₂H₂₁N₃O₆
• 分子量: 303.31
• InChiKey: KRGPXXHMOXVMMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.2
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  153
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Nicotianamine-Derived Metallophore And Processes For Producing Same
  申请人：Dreyfus Cyril

  公开号：US20120095262A1

  公开（公告）日：2012-04-19

  The invention relates to a nicotianamine derivative and to a process for chemical or enzymatic synthesis thereof. The nicotianamine derivative has the following formula (I). The invention finds use in the pharmacy field in particular.

  该发明涉及一种尼古酸胺衍生物及其化学或酶促合成的方法。该尼古酸胺衍生物具有以下化学式（I）。该发明特别适用于药学领域。
• EFFECTIVE PRODUCTION PROCESS FOR MUGINEIC ACID COMPOUND
  申请人：Suntory Holdings Limited

  公开号：EP2103599A1

  公开（公告）日：2009-09-23

  A method for producing mugineic acids, which is represented by the following scheme: (wherein R1 and R2 represent a hydrogen atom or a hydroxyl group, R3 represents a hydroxyl group or an amino group, R4 and R7 represent a hydrogen atom or a protecting group of a carboxyl group, R5 represents a protecting group of an amino group, R6 represents a protecting group of a carboxyl group, and R8 represents -OR9 (wherein R9 represents a protecting group of a hydroxyl group) or -NHR10 (wherein R10 represents a protecting group of an amino group)).

  一种生产麦角酸的方法，由以下方案代表：（其中R1和R2代表氢原子或羟基，R3代表羟基或氨基，R4和R7代表氢原子或羧基的保护基，R5代表氨基的保护基，R6代表羧基的保护基，R8代表-OR9（其中R9代表羟基的保护基）或-NHR10（其中R10代表氨基的保护基）。
• Pyrrole Derivatives As Pharmaceutical Agents
  申请人：Canne Bannen Lynne

  公开号：US20080234270A1

  公开（公告）日：2008-09-25

  Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.

  提供了用于调节受体活性的化合物、组合物和方法。特别提供了用于调节受体活性的化合物和组合物，以及用于治疗、预防或改善与受体活性直接或间接相关的一种或多种疾病或紊乱的症状的方法。
• [EN] HIGHLY WATER-SOLUBLE SALTS OF A SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKER AND USES THEREOF<br/>[FR] SELS TRÈS HYDROSOLUBLES D'UN INHIBITEUR DES CANAUX CALCIQUES À BASE DE PHÉNYLALKYLAMINE À ACTION COURTE ET LEURS UTILISATIONS
  申请人：MILESTONE PHARMACEUTICALS INC

  公开号：WO2016165014A1

  公开（公告）日：2016-10-20

  The present invention includes surprisingly water-soluble salts of a phenylalkylamine compound that are potent antagonists of L-type calcium channels. Aqueous solutions including salts of the instant invention are formulated for nasal administration and provide a novel therapeutic platform for the treatment of stable angina, migraine, and cardiac arrhythmia, such as paroxysmal supraventricular tachycardia.

  本发明包括一种令人惊讶的苯基烷基胺化合物的水溶性盐，这些盐是L型钙通道的有效拮抗剂。包括本发明盐的水溶液被配制用于鼻腔给药，并为稳定型心绞痛、偏头痛和心律失常（如阵发性上室性心动过速）的治疗提供了一种新颖的治疗平台。
• SOY SAUCE HAVING HYPOTENSIVE EFFECTS AND METHOD FOR PRODUCING THE SAME
  申请人：Endo Yoshikazu

  公开号：US20120282243A1

  公开（公告）日：2012-11-08

  The present invention provides soy sauce that comprises significant amounts of peptides, and, in particular, hypotensive peptide Gly-Tyr and hypotensive peptide Ser-Tyr, exhibiting a high degree of angiotensin-I-converting enzyme-inhibitory activity and has hypotensive effects while containing no hypotensive agent. Target soy sauce is obtained by mixing soy sauce koji having protease activity of 20 to 300 U/g koji with an aqueous common salt solution and subjecting the mixture to heated digestion, followed by compression filtration. Target soy sauce with a good flavor is obtained by adding soy sauce lactic acid bacteria and soy sauce yeast cells to the moromi mash after heated digestion, and subjecting the resultant to fermentation and maturation, followed by compression filtration.

  本发明提供了含有大量肽的酱油，特别是含有降压肽Gly-Tyr和降压肽Ser-Tyr，展现出高度的血管紧张素转化酶抑制活性，并具有降压作用，同时不含降压剂。目标酱油是通过将具有20至300 U/g酱油麹菌的蛋白酶活性与水溶性普通盐溶液混合，并经过加热消化，然后进行压缩过滤而获得的。通过在加热消化后向酱油混糜中添加酱油乳酸菌和酱油酵母细胞，并经过发酵和成熟，然后进行压缩过滤，可以获得口感好的目标酱油。