1-[5-(diaminomethylideneazaniumyl)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[5-(diaminomethylideneazaniumyl)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylate
• 化学式: C23H36N6O5S
• 分子量: 508.6
• InChiKey: KXNPVXPOPUZYGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  189
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• THROMBIN FUNCTION COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS BASED ON THEM
  申请人：Sinauridze Elena Ivanovna

  公开号：US20100324058A1

  公开（公告）日：2010-12-23

  This invention relates to new chemical compounds, application of these compound as thrombin inhibitors, and pharmaceutical compositions based on them, and can be used to treat and prevent thrombin-dependent thromboembolic events, and in research.

  这项发明涉及新的化合物，这些化合物作为凝血酶抑制剂的应用，以及基于它们的药物组合物，可用于治疗和预防依赖凝血酶的血栓栓塞事件，并用于研究。
• ANTICOAGULANT REVERSAL AGENTS
  申请人：PEROSPHERE INC.

  公开号：US20170056396A1

  公开（公告）日：2017-03-02

  Novel anticoagulant reversal compounds are disclosed, as well as methods of making the compounds, pharmaceutical compositions including the compounds, methods of using the compounds to reverse the anticoagulant effects of coagulation inhibitors, and diagnostic assays comprising the compounds.

  揭示了新型抗凝血逆转化合物，以及制备该化合物的方法，包括该化合物的制药组合物，使用该化合物逆转凝血抑制剂的抗凝血效果的方法，以及包含该化合物的诊断测定方法。
• Polymer compositions and methods for their use
  申请人：Hunter L. William

  公开号：US20050187140A1

  公开（公告）日：2005-08-25

  Compositions comprising anti-fibrotic agent(s) and/or polymeric compositions can be used in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.

  包含抗纤维化剂和/或聚合物的组合物可用于各种医疗应用，包括预防手术粘连、治疗炎症性关节炎、治疗疤痕和瘢痕疙瘩、治疗血管疾病以及预防软骨流失。
• [EN] PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF<br/>[FR] DÉRIVÉ DE PHOSPHAMIDE, SON PROCÉDÉ DE FABRICATION ET SES UTILISATIONS<br/>[ZH] 一种磷酰胺衍生物及制备方法和用途
  申请人：SICHUAN HAISCO PHARMACEUTICAL CO LTD

  公开号：WO2017133517A1

  公开（公告）日：2017-08-10

  公开了一种磷酰胺衍生物及制备方法和用途。特别公开了一种通式(I)所示化合物及其药学上可接受的盐或立体异构体 (I)，其中，G、L、Q、s如说明书中所定义。
• Methods for reducing platelet activation and for the treatment of thrombotic events
  申请人：Scott A.D. Robert

  公开号：US20070213303A1

  公开（公告）日：2007-09-13

  Methods and compositions for the treatment or prophylaxis of a disorder associated with platelet activation or enhanced thrombin activity are provided, that include the administration of an effective amount of a compound of the formula: or its pharmaceutically acceptable salt, ester or prodrug, wherein the substituents are defined herein, optionally in the appropriate pharmaceutically acceptable carrier for the route of administration selected.