1,2,4,5-tetrakis(mercaptomethyl)benzene | 82456-99-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2,4,5-tetrakis(mercaptomethyl)benzene
• 英文别名: Benzene-1,2,4,5-tetrayltetramethanethiol；[2,4,5-tris(sulfanylmethyl)phenyl]methanethiol
• CAS: 82456-99-3
• 化学式: C₁₀H₁₄S₄
• 分子量: 262.485
• InChiKey: LJODQQVXMSKBHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  4
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2,4,5-tetrakis(mercaptomethyl)benzene 在 sodium hydroxide 、 双氧水 作用下， 以 乙醇 、 氯仿 、 溶剂黄146 为溶剂， 反应 10.0h， 生成 1,2,4,5-Tetrakis(6-chlorohexylsulfonylmethyl)benzene
  参考文献：
  名称：

  Synthesis and Molecular Recognition Properties of a .beta.-Cyclodextrin Tetramer

  摘要：

  The synthesis and binding properties of a cyclodextrin tetramer are described. This species is composed of four individual cyclodextrin subunits covalently appended to a central aromatic core. The tetramer is prepared from beta-cyclodextrin in five steps in an overall 14% yield. We have performed a preliminary survey of the binding properties of this species. The structure of tetramertetraarylporphryin complexes was examined by both NMR and mass spectrometry. The results are consistent with a 1:1 stoichiometry in which the aromatic substituents of the porphyrin moiety are incorporated into the individual cyclodextrin subunits of the tetramer. The cyclodextrin tetramer exhibits a high affinity for both tetraarylporphyrins and metalloporphyrins, with binding constants as large as 10(8) M(-1). Finally, we have compared and contrasted the behavior of the tetrameric species with that of two related cyclodextrin dimers. While all of these hosts bind both porphyrins and metalloporphyrins, the tetramer exhibits a special affinity for those guests that contain a neutral inner porphyrin core.

  DOI：

  10.1021/jo00127a040
• 作为产物：
  描述：

  1,2,4,5-四甲苯 在 氢氧化钾 、 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 生成 1,2,4,5-tetrakis(mercaptomethyl)benzene
  参考文献：
  名称：

  Synthesis of cuppedophanes and cappedophanes. Two new classes of cyclophanes with molecular cavities

  摘要：

  DOI：

  10.1021/jo00290a017

文献信息

• A Dual Wavelength Polymerization and Bioconjugation Strategy for High Throughput Synthesis of Multivalent Ligands
  作者：Zihao Li、Shashank Kosuri、Henry Foster、Jarrod Cohen、Coline Jumeaux、Molly M. Stevens、Robert Chapman、Adam J. Gormley

  DOI：10.1021/jacs.9b09899

  日期：2019.12.18

  side chain of linear polymers or the α-chain end of star polymers. Polymerizations are performed under visible light using an oxygen tolerant porphyrin-catalyzed photoinduced electron/energy transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) process, after which the deprotection and click reaction is triggered by UV light. Using this approach, we are able to precisely control the valency

  由于此类大分子提供的结构多种多样，多价聚合物支架的结构-功能关系非常复杂。由于与制作这些复杂的共轭物相关的实验困难，对这种景观的评估传统上是逐案完成的。在这里，我们介绍了一种简单的双波长、两步聚合和点击方法，用于制作组合共轭文库。它通过将聚合友好的环丙烯酮掩蔽的二苯并环辛炔 (cp-DIBAC) 引入线性聚合物的侧链或星形聚合物的 α 链末端来进行。聚合是在可见光下使用耐氧卟啉催化光诱导电子/能量转移可逆加成断裂链转移 (PET-RAFT) 工艺进行的，之后紫外光触发脱保护和点击反应。使用这种方法，我们能够以有利于高通量合成的方式精确控制聚合物支架上配体的价态和位置。
• Structure and Conformational Properties of three-layered Cyclophanes prepared by a one-pot Synthesis
  作者：Akihiko Tsuge、Takahiro Okamoto、Tetsuji Moriguch

  DOI：10.3184/030823407x228786

  日期：2007.7

  The coupling reactions of substituted bis(bromomethyl)benzene components and tetra(mercaptomethyl)benzene derivatives have been carried out under heterogeneous dilute reaction conditions to afford the three-layered cyclophanes 3a–e as three kinds of conformational isomers in moderate yields.

  在异相稀释反应条件下，对取代的双（溴甲基）苯组分和四（巯甲基）苯衍生物进行了偶联反应，以中等产率得到了三种构象异构体的三层环烷 3a-e。
• Synthesis, Structure, and Properties of Triple-Layered [2.2][2.2]Naphthalenophane
  作者：Tetsuo Otsubo、Yoshio Aso、Fumio Ogura、Soichi Misumi、Atsushi Kawamoto、Jiro Tanaka

  DOI：10.1246/bcsj.62.164

  日期：1989.1

  to a simple access to triple-layered [2.2][2.2]paracyclophane. Its structure was elucidated by X-ray crystallographic analysis. The outer naphthalene rings are bent into a boat form and the inner naphthalene ring is bent into a twist form. These naphthalenes are stacked in layers within van der Waals contact. Therefore, there is a strong transannular π-electronic interaction between them, which brings

  标题化合物的合成方式与简单获得三层 [2.2][2.2] 对环芳烷类似。通过X射线晶体学分析阐明了其结构。外萘环弯曲成船形，内萘环弯曲成扭曲形式。这些萘在范德华接触内分层堆叠。因此，它们之间存在强烈的跨环π-电子相互作用，从而导致特征红移、增色和电子光谱增宽。这些效果比双层同系物的效果更突出。
• CHROMENE COMPOUND, CURABLE COMPOSITION COMPRISING THE COMPOUND, AND OPTICAL ARTICLE INCLUDING A CURED BODY OF THE CURABLE COMPOSITION
  申请人：TOKUYAMA CORPORATION

  公开号：US20200190106A1

  公开（公告）日：2020-06-18

  A chromene compound having at least one indenonaphthopyran moiety which has a group forming a spiro ring together with the 13-position carbon atom and further an oligomer chain group selected from a polyalkylene oxide oligomer chain group having at least three recurring units and a polyester oligomer chain group having at least three recurring units, represented by the following formula and having reduced matrix dependence: wherein R 1 and R 2 are each a group which may have an oligomer chain group, the ring Z bonded to the 13-position carbon atom of the chromene compound is a Spiro ring group, and R 3 and R 4 are each an aryl group or heteroaryl group which may have an oligomer chain group. Preferably, the chromene compound has at least one oligomer chain group in the molecule.

  具有至少一个印苯并萘吡喃基团的色酮化合物，其中该基团与13位碳原子形成螺环，并且进一步具有从至少三个重复单元中选择的聚烷氧基寡聚物链基团和聚酯寡聚物链基团中的一个寡聚物链基团，由下式表示并具有降低的矩阵依赖性： 其中R1和R2是各自可能具有寡聚物链基团的基团，与色酮化合物的13位碳原子键合的环Z是螺环基团，而R3和R4是各自可能具有寡聚物链基团的芳基或杂环基团。最好，该色酮化合物在分子中至少具有一个寡聚物链基团。
• METAL COMPOUND, POLYMERIZABLE COMPOSITION CONTAINING THE SAME, RESIN, METHOD FOR PRODUCING THE RESIN, AND USE OF THE RESIN
  申请人：Murakami Masakazu

  公开号：US20110136977A1

  公开（公告）日：2011-06-09

  Disclosed is a metal compound represented by the following formula (0): in the formula (0), A represents a thietane ring, or a monovalent group containing a thiol group; B represents a divalent group containing a heteroatom; R 2 represents a divalent organic group; n represents the valence of M; p represents an integer of 1 ton; M represents a lanthanoid atom or a barium (Ba) atom when A is a thietane ring, and represents a lanthanoid atom when A is a monovalent group containing a thiol group; or more than Y represents a monovalent inorganic or organic group; when n−p is not less than 2, a plurality of Y's each independently represent a monovalent inorganic or organic group; and when n−p is not less than 2, the plurality of Y's may be bonded with each other to form a ring containing M.

  揭示了一种由以下公式（0）表示的金属化合物： 在公式（0）中，A表示噻吩环或含有硫醇基的一价基团；B表示含有杂原子的二价基团；R2表示二价有机基团；n表示M的价；p表示1到n的整数；当A是噻吩环时，M表示镧系元素或钡（Ba）原子，当A是含有硫醇基的一价基团时，M表示镧系元素；Y表示一价无机或有机基团，当n-p不小于2时，多个Y可以各自独立地表示一价无机或有机基团；当n-p不小于2时，多个Y可以彼此连接形成含有M的环。