gamma-Glutamyllysine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: gamma-Glutamyllysine
• 英文别名: 6-amino-2-[(4-amino-4-carboxybutanoyl)amino]hexanoic acid
• 化学式: C₁₁H₂₁N₃O₅
• 分子量: 275.3
• InChiKey: LNLLNTMHVMIMOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.3
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  156
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• TRANSGLUTAMINASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20130102633A1

  公开（公告）日：2013-04-25

  Transglutaminase inhibitors and methods of use thereof are provided.

  本发明提供了谷氨酰胺转移酶抑制剂及其使用方法。
• Recombinant hybrid immunoglobulin molecules and their use
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：EP0271227A2

  公开（公告）日：1988-06-15

  This invention relates to a recombinant hybrid immunoglobulin molecule having an antigen binding site specific for fibrin linked to a second protein compris­ing the active portion of a plasminogen activator. The invention is also directed to the cloning and produc­tion of these novel hybrid immunoglobulin molecules. This invention further relates to a method of using these recombinant hybrid immunoglobulin molecules in immunodiagnostic and immunotherapeutic processes.

  本发明涉及一种重组杂交免疫球蛋白分子，该分子具有特异于纤维蛋白的抗原结合位点，并与包含纤溶酶原激活剂活性部分的第二种蛋白质相连接。本发明还涉及这些新型杂交免疫球蛋白分子的克隆和生产。本发明还涉及在免疫诊断和免疫治疗过程中使用这些重组混合免疫球蛋白分子的方法。
• Viral-safe purified human thrombin
  申请人：BAXTER INTERNATIONAL INC.

  公开号：EP0443724A1

  公开（公告）日：1991-08-28

  A viral-safe highly purified human thrombin is prepared by a commercial-scale process utilizing antiviral agents integral to a purification scheme employing ion exchange mass capture and S-sepharose affinity chromotography. The resultant thrombin product is therapeutically acceptable for human administrations.

  利用离子交换质量捕获和 S-sepharose亲和层析的纯化方案中不可或缺的抗病毒剂，通过商业规模的工艺制备出病毒安全的高纯度人凝血酶。 制备出的凝血酶产品可用于人体治疗。
• Recombinant hybrid immunoglobulin molecules and method of use
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：EP0478366A2

  公开（公告）日：1992-04-01

  A recombinant chimeric immunoglobulin molecule is disclosed which has an antigen binding site specific for fibrin linked to the active portion of a plasminogen activator, such as urokinase.

  本研究公开了一种重组嵌合免疫球蛋白分子，它具有一个特异于纤维蛋白的抗原结合位点，该位点与纤溶酶原激活剂（如尿激酶）的活性部分相连接。
• Process for efficiently producing transglutaminase through DNA recombination
  申请人：Ajinomoto Co., Inc.

  公开号：EP0743365A2

  公开（公告）日：1996-11-20

  The present invention relates to a process for producing a transglutaminase, which comprises incubating Escherichia coli expressing genes encoding a heat shock protein (DnaJ) and a transglutaminase. The transglutaminase is produced in large quantities, at low cost and has the appropriate stereostructure to render the transglutaminase biologically active. The transglutaminase so produced is useful in the food industry.

  本发明涉及一种生产转谷氨酰胺酶的工艺，它包括培养表达编码热休克蛋白（DnaJ）和转谷氨酰胺酶基因的大肠杆菌。转谷氨酰胺酶的生产量大、成本低，并具有适当的立体结构，使转谷氨酰胺酶具有生物活性。生产出的转谷氨酰胺酶可用于食品工业。