3,3-Dimethyl-2-oxabicyclo[2.2.2]oct-5-ene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 3,3-Dimethyl-2-oxabicyclo[2.2.2]oct-5-ene
• 化学式: C₉H₁₄O
• 分子量: 138.21
• InChiKey: LSIBZCUWRZPYFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Bicyclo 4.4.0 antiviral derivatives
  申请人：——

  公开号：US20040009985A1

  公开（公告）日：2004-01-15

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

  这项发明提供了具有药物和生物影响特性的化合物，它们的药物组合物和使用方法。具体而言，该发明涉及酰胺哌嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药物、抗感染剂、免疫调节剂或HIV进入抑制剂结合使用。更具体地说，本发明涉及治疗HIV和艾滋病。
• POLYMERIC MATERIALS
  申请人：Graichen Florian Hans Maximilian

  公开号：US20160075716A1

  公开（公告）日：2016-03-17

  The present invention relates to a polymer comprising as part of its polymer backbone a moiety of Formula (II): where one of R 6 to R 10 represents A-O— and one of R 6 to R 10 represents —O—B and the remainder of R 6 to R 10 represent H, where A and B represent the remainder of the polymer backbone and may be the same or different.

  本发明涉及一种聚合物，其聚合骨架的一部分包括式（II）的基团：其中R6至R10中的一个表示A-O—，R6至R10中的一个表示—O—B，而R6至R10的其余部分表示H，其中A和B表示聚合骨架的其余部分，可以相同也可以不同。
• METHOD FOR THE PRODUCTION OF TAXOL AND/OR TAXANES FROM CULTURES OF HAZEL CELLS
  申请人：Miele Mariangela

  公开号：US20070026506A1

  公开（公告）日：2007-02-01

  Method for the production of taxol and/or taxanes, comprising the steps of: a) inducing the formation of callus from a plant tissue explant, through in vitro culturing in a suitable nutritient medium, b) cultivating the callus in a liquid medium to obtain a cell suspension culture capable of producing taxol and/or taxanes, c) recovering the taxol and/or the taxanes from the cells and/or from the culture medium of the cell suspension obtained from the callus in which the tissue explant is obtained from a plant of the genus Corylus , in particular Corylus avellana.

  生产紫杉醇和/或紫杉烷类化合物的方法，包括以下步骤：a）通过在适宜的营养培养基中进行离体培养，诱导植物组织外植体形成愈伤组织，b）在液体培养基中培养愈伤组织以获得能够产生紫杉醇和/或紫杉烷类化合物的细胞悬浮液培养物，c）从细胞和/或从愈伤组织所得的细胞悬浮液培养物中回收紫杉醇和/或紫杉烷类化合物，其中所述的组织外植体来自榛属植物，特别是榛树（Corylus avellana）。
• EXTERNAL PREPARATION CONTAINING ANALGESIC/ANTI-INFLAMMATORY AGENT
  申请人：Miura Seiji

  公开号：US20110319399A1

  公开（公告）日：2011-12-29

  An external preparation containing the following components (A) and (B): (A) a non-steroidal analgesic/anti-inflammatory agent, and (B) an organic amine. The external preparation of the present invention has improved skin permeation and excellent stability of a non-steroidal analgesic/anti-inflammatory agent in the external preparation. The external preparation of the present invention also has excellent appearance.

  一种外用制剂，包含以下成分(A)和(B)：(A)非甾体类镇痛/抗炎药物，以及(B)有机胺。本发明的外用制剂具有改善皮肤渗透性和非甾体类镇痛/抗炎药物在外用制剂中的优异稳定性。本发明的外用制剂还具有优异的外观。
• 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
  申请人：Bradbury James Barton

  公开号：US20070049586A1

  公开（公告）日：2007-03-01

  The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: Such compounds possess useful antimicrobial activity. The variables R 2 , R 3 , R 5 , R 6 , R 7 , and R 9 shown in Formula A and B are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.

  本发明提供了公式I和II的化合物和盐，其中包括公式A和公式B的化合物：这些化合物具有有用的抗微生物活性。公式A和B中显示的变量R2、R3、R5、R6、R7和R9在此定义。本文所披露的公式I和公式II的某些化合物是强效和/或选择性的细菌DNA合成和细菌复制抑制剂。本发明还提供了抗微生物组合物，包括含有公式I或公式II中一个或多个化合物和一个或多个载体、赋形剂或稀释剂的制药组合物。这些组合物可以仅包含公式I或公式II中的一个化合物作为唯一活性剂，也可以包含公式I或公式II中的一个化合物和一个或多个其他活性剂的组合物。本发明还提供了治疗动物微生物感染的方法。