Dispiro(isobenzofuran-1(3H),1'-cyclobutane-2',1''(3''H)-isobenzofuran)-3,3''-dione, 6,6'',7,7''-tetrahydro-3',4'-dipropyl- | 90826-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异苯并呋喃
• 英文名称: Dispiro(isobenzofuran-1(3H),1'-cyclobutane-2',1''(3''H)-isobenzofuran)-3,3''-dione, 6,6'',7,7''-tetrahydro-3',4'-dipropyl-
• CAS: 90826-58-7
• 化学式: C₂₄H₂₈O₄
• 分子量: 380.5
• InChiKey: LSDFCPDLBLFHAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Use of Phthalide Derivatives
  申请人：Chen Fei

  公开号：US20080255061A1

  公开（公告）日：2008-10-16

  Disclosed a class of phthalide derivatives and the use of which to manufacture the sensitizer or reverser of the antineoplastic agent. The phthalide derivatives according to the invention can enhance the sensitivity of drug-resistance tumor cells against chemotherapy and decrease the drug-resistance of tumor cells 5-30 folder and enhance notably several chemotherapy agents-induced apoptosis of tumor cells
• ANTI-TUMOR EFFECT OF DIMERIC PHTHALIDE COMPOUND
  申请人：Chen Fei

  公开号：US20100010081A1

  公开（公告）日：2010-01-14

  The present invention provides for the use of a dimeric phthalide compound, the dimeric phthalide compound has broad anti-tumor activity, can directly inhibit the proliferation of tumor cells and induce cell death, but also indirectly inhibit the development of tumors by suppressing neovascularization. And further, the dimeric phthalide compound can be used alone or in combination to treat cancer, as well as in combination with chemotherapeutics to increase the efficacy of chemotherapeutics and decrease the toxicity of chemotherapeutics.
• US8247444B2
  申请人：——

  公开号：US8247444B2

  公开（公告）日：2012-08-21
• US8445532B2
  申请人：——

  公开号：US8445532B2

  公开（公告）日：2013-05-21