Malonyl coenzyme A lithium salt

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Malonyl coenzyme A lithium salt
• 英文别名: 3-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3-oxopropanoic acid
• 化学式: C₂₄H₃₈N₇O₁₉P₃S
• 分子量: 853.6
• InChiKey: LTYOQGRJFJAKNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  54
• 可旋转键数：
  22
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  426
• 氢给体数：
  10
• 氢受体数：
  24

文献信息

• Malonate transporters
  申请人：CB Therapeutics, Inc.

  公开号：US11041002B1

  公开（公告）日：2021-06-22

  The methods and systems disclose enzymes that function to import malonic acid or malonates into a cell. The enzymes increase the output of precursor molecules by enriching certain pathways in the cell. The precursor molecules can be converted to cannabinoids. The enzymes are a family of proteins which have a majority of common alignments.

  这些方法和系统公开了具有将丙二酸或丙二酸盐输入细胞功能的酶。这些酶通过丰富细胞中的某些途径来增加前体分子的输出。前体分子可转化为大麻素。这些酶是一个蛋白质家族，有大多数共同的排列方式。
• REDUCING BYPRODUCTION OF MALONATES IN A FERMENTATION PROCESS
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2358862A1

  公开（公告）日：2011-08-24
• HIGH EICOSAPENTAENOIC ACID OILS FROM IMPROVED OPTIMIZED STRAINS OF YARROWIA LIPOLYTICA
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2442666B1

  公开（公告）日：2015-04-08
• IMPROVED OPTIMIZED STRAINS OF YARROWIA LIPOLYTICA FOR HIGH EICOSAPENTAENOIC ACID PRODUCTION
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2475679A1

  公开（公告）日：2012-07-18
• OPTIMIZED STRAINS OF YARROWIA LIPOLYTICA FOR HIGH EICOSAPENTAENOIC ACID PRODUCTION
  申请人：Hong Seung-Pyo

  公开号：US20100317072A1

  公开（公告）日：2010-12-16

  Described are engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing an oil comprising greater than 50 weight percent of eicosapentaenoic acid [“EPA”], an ω-3 polyunsaturated fatty acid, measured as a weight percent of total fatty acids [“% TFAs”] and having a ratio of at least 3.1 of EPA % TFAs, to linoleic acid, measured as % TFAs. These strains over-express at least one Δ9 elongase/Δ8 desaturase multizyme, in addition to other heterologous Δ9 elongases, Δ8 desaturases, Δ5 desaturases, Δ17 desaturases, Δ12 desaturases, C 16/18 elongases, and optionally over-express diacylglycerol cholinephosphotransferases, malonyl CoA synthetases and/or acyl-CoA lysophospholipid acyltransferases. The expression of at least one peroxisome biogenesis factor protein is down-regulated. Methods for producing EPA within said host cells, oils obtained from the cells, and products therefrom are claimed.