Pentacosan-1-carbonsaeure-amid | 22715-86-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Pentacosan-1-carbonsaeure-amid
• 英文别名: Hexacosansaeureamid；Hexacosanamide
• CAS: 22715-86-2
• 化学式: C₂₆H₅₃NO
• 分子量: 395.713
• InChiKey: LUOABWGXXKLFGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.1
• 重原子数：
  28
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] CANCER VACCINE<br/>[FR] VACCIN ANTI-CANCER
  申请人：VICTORIA LINK LTD

  公开号：WO2021045632A1

  公开（公告）日：2021-03-11

  The invention relates to a combination of a TLR-9 agonist and a conjugate of Formula (I) or pharmaceutically acceptable salt thereof. (Formula (I))

  本发明涉及TLR-9激动剂与式(I)的偶联物或其药物可接受的盐的联合使用。 (式(I))
• Novel ultrasound contrast agents
  申请人：——

  公开号：US20040170565A1

  公开（公告）日：2004-09-02

  New ultrasound contrast agents that comprise microbubbles encapsulating a gas within a shell made from a blend of bipolar compounds having mixed carbon chain length. The compounds have hydrophobic groups selected from the group consisting of straight-chained alkyls, alkylethers, alkylthiolethers, alkyldisulfides, polyfluoroalkyls, and polyfluoroalkylethers having a carbon chain length greater than or equal to 16 and less than or equal to 32. The polar groups are connected to the hydrophobic groups by means of a linker. The polar head groups are selected from the group consisting of CO 2 -M + , SO 3 − M + , SO 4 − M + , PO 3 − M + , PO 4 − M + 2 , N(R) 4 + , a pyridinium or substituted pyridinium group, and a zwitterionic group; R is selected from the group consisting of —H, —CH 3 , alkyl, cycloalkyl, substituted cycloalkyls containing one or more heteroatoms, and benzyl and can be the same or different; and Z′ is a nonionic and M is a cation.

  新的超声造影剂包括微泡，其内部封装有气体，外壳由混合的双极化合物制成，其碳链长度混合。这些化合物具有疏水基团，所选的疏水基团来自于直链烷基，烷基醚，烷基硫醚，烷基二硫化物，多氟烷基和碳链长度大于或等于16且小于或等于32的多氟烷基醚。极性基团通过连接剂连接到疏水基团上。极性头基团来自于CO2-M+，SO3−M+，SO4−M+，PO3−M+，PO4−M+2，N(R)4+，吡啶或取代吡啶基团和带电离子的基团；R来自于—H，—CH3，烷基，环烷基，含有一个或多个杂原子的取代环烷基和苄基，并且可以相同也可以不同；Z′是非离子性的，M是一个阳离子。
• METHODS AND COMPOSITIONS FOR TREATING DEGENERATIVE AND ISCHEMIC DISORDERS
  申请人：Mootha Vamsi K.

  公开号：US20120136007A1

  公开（公告）日：2012-05-31

  Model systems have shown that shifting a cell's reliance from oxidative phosphorylation (OXPHOS) to glycolysis can protect against cell death. Exploiting the therapeutic potential of this strategy, however, has been limited by the lack of clinically safe agents that remodel energy metabolism. The present invention identifies non-toxic small molecules (e.g., drug-like compounds) that are capable of modulating oxidative metabolism. One identified compound comprises meclizine. As described herein, meclizine, and its enantiomer S-meclizine, redirects OXPHOS to glycolysis. Such compounds could be protective or therapeutic in degenerative disorders such as diabetes, Huntington's, Parkinson's, and Alzheimer's disease and/or ischemic disorders including, but not limited to, stroke, heart attack, or reperfusion injuries.

  模型系统表明，将细胞从氧化磷酸化（OXPHOS）转向糖酵解可以保护细胞免受死亡的影响。然而，利用这种策略的治疗潜力受到了缺乏临床安全制剂来重塑能量代谢的限制。本发明确定了能够调节氧化代谢的非毒性小分子（例如药物类化合物）。其中一种已确定的化合物包括美克林。如本文所述，美克林及其对映体S-美克林将OXPHOS重定向到糖酵解。这样的化合物可以在退行性疾病（如糖尿病、亨廷顿病、帕金森病和阿尔茨海默病）以及缺血性疾病（包括但不限于中风、心脏病发作或再灌注损伤）中具有保护或治疗作用。
• METHODS, COMPOSITIONS AND KITS FOR PROMOTING MOTOR NEURON SURVIVAL AND TREATING AND DIAGNOSING NEURODEGENERATIVE DISORDERS
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20160082015A1

  公开（公告）日：2016-03-24

  Methods, compositions, and kits for promoting motor neuron survival and for treatment and diagnosis of neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS) and Spinal muscular atrophy (SMA) are described herein.

  本文描述了促进运动神经元存活以及治疗和诊断神经退行性疾病，如肌萎缩侧索硬化症（ALS）和脊髓性肌萎缩症（SMA）的方法、组合物和试剂盒。
• Magnet wire
  申请人：SUMITOMO ELECTRIC INDUSTRIES LIMITED

  公开号：EP0033224A1

  公开（公告）日：1981-08-05

  A magnet wire comprises a conductor having thereon an outermost insulating wire enamel layer, either directly or over another insulating layer. The wire enamel consists essentially of a polyamideimide wherein one or both ends of at least one polyamideimide molecule is a terminal linear alkyl group having at least 21 carbon atoms. The magnet wire has a high resistance to refrigerant as well as to thermal or mechanical damage and has a high lubricity.

  电磁线包括导体，导体上有一层最外层的绝缘漆包线层，可以直接绝缘，也可以覆盖在另一层绝缘漆包线层上。漆包线漆主要由聚酰胺酰亚胺组成，其中至少一个聚酰胺酰亚胺分子的一端或两端是具有至少 21 个碳原子的末端直链烷基。漆包线对制冷剂以及热损伤或机械损伤具有很高的耐受性，并且具有很高的润滑性。