Bioaffinity and ion exchange separations with liquid exchange supports
申请人:E.I. DU PONT DE NEMOURS AND COMPANY
公开号:EP0246103A2
公开(公告)日:1987-11-19
Bioaffinity and ion-exchange separation methods are provided along with liquid supports utilized in these methods. The support is based on an inert carrier with ligands or binders attached to its surface. Methods for preparing such supports and their use in capturing neutral and charged target molecules from samples and in analytical applications are also provided.
Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
申请人:E.I. DU PONT DE NEMOURS AND COMPANY
公开号:EP0281368A2
公开(公告)日:1988-09-07
A bioaffinity separation method is provided along with a solid affinity support utilized in that method. Additionally, immobilized enzyme systems are provided for use as enzyme electrode systems. The support is based on an inert carrier with ligands or binders attached to its surface. Methods for preparing such supports and their use in capturing target molecules from samples and in analytical applications are also provided.
POLY(FLUOROALKYL) SUGAR REAGENTS AND THEIR USE FOR SURFACE MODIFICATION
申请人:E.I. DU PONT DE NEMOURS AND COMPANY
公开号:EP0549665A1
公开(公告)日:1993-07-07
MASS TAGS FOR MASS SPECTROMETRIC ANALYSIS OF IMMUNOGLOBULINS
申请人:Yost Richard A.
公开号:US20120196297A1
公开(公告)日:2012-08-02
The present invention is a method for the characterization or detection of one or more antibodies in a sample. The method comprises obtaining a tagged antigen comprising an antigen and a mass tag attached to the antigen. The tagged antigen has specificity for the antibody. In addition, the method comprises combining the tagged antigen with the antibody to form a tagged antigen-antibody complex. Further, the method comprises cleaving the mass tag from the tagged antigen-antibody complex. Thereafter, the method comprises analyzing the mass tag via a mass spectrometer to determine the presence of the mass tag in the sample and correlating the presence of the mass tag with a presence of the antibody in the sample.