3-Hydroxy-2-(octadec-9-enoylamino)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Hydroxy-2-(octadec-9-enoylamino)propanoic acid
• 化学式: C₂₁H₃₉NO₄
• 分子量: 369.5
• InChiKey: MBDKGXAMSZIDKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  26
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] FATTY ACID AMIDES AND USES THEREOF IN THE TREATMENT OF ADDICTION DISORDER AND ADDICTION RELATED CONDITIONS<br/>[FR] AMIDES D'ACIDES GRAS ET LEURS UTILISATIONS DANS LE TRAITEMENT DE TROUBLES DE LA DÉPENDANCE ET D'ÉTATS LIÉS À LA DÉPENDANCE
  申请人：YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD

  公开号：WO2018216008A1

  公开（公告）日：2018-11-29

  The present invention is directed to a fatty acid amide of an amino acid, including a stereoisomer and a salt thereof for use in the treatment of a patient suffering from any type of addiction disorder, substance abuse disorder, including any condition and symptom associated therewith and including withdrawal syndrome and relapse addiction during and after a rehabilitation treatment of said patient.

  本发明涉及一种氨基酸的脂肪酸酰胺，包括其立体异构体和盐，用于治疗患有任何类型的成瘾障碍、物质滥用障碍的患者，包括与之相关的任何病症和症状，包括戒断综合征以及在患者康复治疗期间和之后的复发成瘾。
• PREPARATION OF AMINO ACID-FATTY ACID AMIDES
  申请人：Chaudhuri Shan

  公开号：US20080200704A1

  公开（公告）日：2008-08-21

  The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an amide linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

  本发明描述了由氨基酸分子和脂肪酸分子产生的化合物。这些化合物采用酰胺键结合的氨基脂肪酸化合物的形式存在，或者是由氨基酸或其衍生物与先前与硫酰卤反应的适当脂肪酸反应而成的混合物。这些分子的使用可提供具有增强生物利用度和特定脂肪酸所赋予的额外益处的补充氨基酸。
• FATTY ACID AMIDES AND USES THEREOF
  申请人：Mechoulam Raphael

  公开号：US20110046222A1

  公开（公告）日：2011-02-24

  Provided are fatty acid amides of amino acids, uses thereof and pharmaceutical compositions including them.

  提供了氨基酸脂肪酰胺，以及其用途和包含它们的药物组成物。
• Fatty acid amides and uses thereof in the treatment of addiction disorder and addiction related conditions
  申请人：Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.

  公开号：US11324709B2

  公开（公告）日：2022-05-10

  The present invention is directed to a fatty acid amide of an amino acid, including a stereoisomer and a salt thereof for use in the treatment of a patient suffering from any type of addiction disorder, substance abuse disorder, including any condition and symptom associated therewith and including withdrawal syndrome and relapse addiction during and after a rehabilitation treatment of said patient.

  本发明涉及一种氨基酸的脂肪酸酰胺，包括其立体异构体和盐，用于治疗患有任何类型成瘾症、药物滥用症的患者，包括与之相关的任何病症和症状，包括在所述患者康复治疗期间和之后的戒断综合征和复吸成瘾。
• FATTY ACID AMIDES AND USES THEREOF IN THE TREATMENT OF ADDICTION DISORDER AND ADDICTION RELATED CONDITIONS
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

  公开号：EP3630087A1

  公开（公告）日：2020-04-08