2-Amino-5-((1-((carboxymethyl)amino)-3-(octylthio)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-5-((1-((carboxymethyl)amino)-3-(octylthio)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid
• 英文别名: 2-amino-5-[[1-(carboxymethylamino)-3-octylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
• 化学式: C₁₈H₃₃N₃O₆S
• 分子量: 419.5
• InChiKey: MJWCZWAVSJZQNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  28
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  184
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• Composition and methods for inhibition of metal corrosion for use in the oil and gas industry
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US10323327B2

  公开（公告）日：2019-06-18

  Corrosion inhibiting compositions and methods of inhibiting corrosion on a metal surface commonly used in the petroleum industry is disclosed. The corrosion inhibitor includes at least one azole, at least one polypeptide derived from amino acid, at least one intensifier preferably from metal halides, and at least one surfactant. The methods include combining effective amounts of the corrosion inhibitor composition and contacting a metal surface in aqueous environment commonly found in oil and gas industry. The composition is very effective against corrosion of metals in contact with aqueous media when used in a dosage as low as 50 ppm.

  本发明公开了抑制石油工业常用金属表面腐蚀的缓蚀组合物和方法。缓蚀剂包括至少一种唑、至少一种由氨基酸衍生的多肽、至少一种优选由金属卤化物衍生的增强剂和至少一种表面活性剂。方法包括将有效量的缓蚀剂组合物与石油和天然气工业中常见的水环境中的金属表面接触。当使用剂量低至 50 ppm 时，该组合物对与水介质接触的金属腐蚀非常有效。
• Targeted liposomal delivery of cGMP analogues
  申请人：Mireca Medicines GmbH

  公开号：US10322087B2

  公开（公告）日：2019-06-18

  The invention relates to means and methods of targeted drug delivery of therapeutic agent to and across the blood-ocular barrier. In particular, the invention relates to cyclic guanosine-3′, 5′-monophosphate analogs as therapeutic agent for treating retinal diseases. The cGMPSs targeted to the blood-ocular barrier by glutathione-based ligands that facilitate the specific binding to and enhanced internalization by glutathione transporters present on the blood-ocular barrier. The glutathione-based ligands are conjugated to nanocontainers such as liposomes encapsulating the cGMPSs.

  本发明涉及将治疗剂靶向输送到血眼屏障并穿过血眼屏障的手段和方法。特别是，本发明涉及环鸟苷-3′，5′-单磷酸类似物作为治疗视网膜疾病的治疗剂。环鸟苷-3′，5′-单磷酸类似物通过谷胱甘肽配体靶向血眼屏障，促进与存在于血眼屏障上的谷胱甘肽转运体的特异性结合和增强内化。谷胱甘肽配体与包裹 cGMPSs 的脂质体等纳米容器共轭。
• Method for inhibiting metal corrosion using a benzimidazole-containing composition
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US11124883B2

  公开（公告）日：2021-09-21

  Corrosion inhibiting compositions and methods of inhibiting corrosion on a metal surface commonly used in the petroleum industry is disclosed. The corrosion inhibitor includes at least one azole, at least one polypeptide derived from amino acid, at least one intensifier preferably from metal halides, and at least one surfactant. The methods include combining effective amounts of the corrosion inhibitor composition and contacting a metal surface in aqueous environment commonly found in oil and gas industry. The composition is very effective against corrosion of metals in contact with aqueous media when used in a dosage as low as 50 ppm.

  本发明公开了抑制石油工业常用金属表面腐蚀的缓蚀组合物和方法。缓蚀剂包括至少一种唑、至少一种由氨基酸衍生的多肽、至少一种优选由金属卤化物衍生的增强剂和至少一种表面活性剂。方法包括将有效量的缓蚀剂组合物与石油和天然气工业中常见的水环境中的金属表面接触。当使用剂量低至 50 ppm 时，该组合物对与水介质接触的金属腐蚀非常有效。
• Benzimidazole composition for metal corrosion inhibition
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US11124882B2

  公开（公告）日：2021-09-21

  Corrosion inhibiting compositions and methods of inhibiting corrosion on a metal surface commonly used in the petroleum industry is disclosed. The corrosion inhibitor includes at least one azole, at least one polypeptide derived from amino acid, at least one intensifier preferably from metal halides, and at least one surfactant. The methods include combining effective amounts of the corrosion inhibitor composition and contacting a metal surface in aqueous environment commonly found in oil and gas industry. The composition is very effective against corrosion of metals in contact with aqueous media when used in a dosage as low as 50 ppm.

  本发明公开了抑制石油工业常用金属表面腐蚀的缓蚀组合物和方法。缓蚀剂包括至少一种唑、至少一种由氨基酸衍生的多肽、至少一种优选由金属卤化物衍生的增强剂和至少一种表面活性剂。方法包括将有效量的缓蚀剂组合物与石油和天然气工业中常见的水环境中的金属表面接触。当使用剂量低至 50 ppm 时，该组合物对与水介质接触的金属腐蚀非常有效。