Elenaic acid | 34422-12-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Elenaic acid
• 英文别名: 2-(3-formyl-5-methoxycarbonyl-2-methyl-3,4-dihydro-2H-pyran-4-yl)acetic acid
• CAS: 34422-12-3
• 化学式: C₁₁H₁₄O₆
• 分子量: 242.22
• InChiKey: MQFAJBBHEYTHKF-UHFFFAOYSA-N

物化性质

• 沸点：
  408.9±45.0 °C(Predicted)
• 密度：
  1.308±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、乙酸乙酯（少许）、甲醇（少许）
• LogP：
  0.220 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Process for obtaining hydroxytyrosol from olive leaves extracts
  申请人：Cognis IP Management GmbH

  公开号：EP1582512A1

  公开（公告）日：2005-10-05

  The present invention refers to a new process for obtaining hydroxytyrosol, by (a) subjecting extracts of olive leaves to hydrolysis in order to obtain an aqueous mixture which is rich in hydroxytyrosol, (b) mixing the intermediate thus obtained with a micro porous resin in order to adsorb the hydroxytyrosol on said matrix and to keep the unwanted by-products within the aqueous phase, and finally (c) separating the matrix from the aqueous phase and desorbing the hydroxytyrosol by means of a suitable solvent.

  本发明涉及一种获取羟基酪醇的新工艺，方法包括(a)将橄榄叶提取物进行水解，以获得富含羟基酪醇的水溶液混合物，(b)将所得的中间产物与微孔树脂混合，以吸附羟基酪醇在该基质上并将不需要的副产物保留在水相中，最后(c)将基质与水相分离，并通过适当的溶剂脱附羟基酪醇。
• Process to extract phenolic compounds from a residual plant material using a hydrothermal treament
  申请人：Centro de Investigaciones Energeticas

  公开号：US20040176647A1

  公开（公告）日：2004-09-09

  The hydrothermal treatment is based on placing the crude residual plant material in contact with hot water in a closed reactor, comprising the following steps: a) placing the material to be treated in contact with water in a closed reactor, and adjusting the solid/liquid ratio so that it ranges from 1/5 to 1/15 (w/v): b) stirring; c) heating to a temperature between 180 and 240° C., and at a pressure so that the water is maintained in liquid phase; d) constantly stirring the mixture for a time period between 4 and 30 minutes; and e) cooling the reactor to approximately 40° C., unloading the mixture, filtering and recovering the liquid fraction.

  水热处理是基于将原始残留植物材料与热水接触在一个封闭反应器中，包括以下步骤：a) 将待处理材料与水接触在一个封闭反应器中，并调整固液比，使其范围在1/5到1/15（w/v）之间；b) 搅拌；c) 加热至180至240°C的温度，并在压力下使水保持液态；d) 持续搅拌混合物，时间为4至30分钟；以及e) 冷却反应器至约40°C，卸载混合物，过滤和回收液相。
• Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus
  申请人：Lee-Huang Sylvia

  公开号：US20090061031A1

  公开（公告）日：2009-03-05

  The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.

  本发明涉及一种治疗肥胖或肥胖相关疾病的方法和制药组合物，该方法适用于患有或易于发展肥胖或肥胖相关疾病的个体，或用于抑制HIV的感染，通过给予欧洲橄榄苦苷、其类似物或衍生物，或欧洲橄榄苦苷的主要代谢产物，包括欧洲橄榄苦苷去糖基体、羟基酪醇和环醇酸或其类似物、衍生物、一种虫草苷苷苷或一种secoiridoid苷苷苷或其类似物或衍生物，或上述任何组合，包括橄榄叶提取物。本发明还涉及通过测量从PPARγ2、LPL和αP2基因和基因产物选择的脂肪生成基因或其他脂肪生成、脂肪合成或脂解基因和基因产物的表达谱来筛选/诊断患有或易于患有肥胖或相关疾病的个体的方法。本发明还提供了筛选新欧洲橄榄苦苷类似物的方法。
• Compositions and Methods for Treating Obesity, Obesity Related Disorders and for Inhibiting the Infectivity of Human Immunodeficiency Virus
  申请人：The General Hospital Corporation

  公开号：US20140296141A1

  公开（公告）日：2014-10-02

  The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.

  本发明涉及使用欧洲橄榄苷、其类似物或衍生物，或欧洲橄榄苷的主要代谢产物，包括欧洲橄榄苷苷元、羟基酪醇和羟基酪醛酸或其类似物或衍生物、半萜苷苷元或半萜苷苷元类似物或衍生物，或上述任何组合物，包括橄榄叶提取物，用于治疗患有或易于发展肥胖症或肥胖相关疾病的受体，或用于抑制HIV的感染。本发明还涉及通过测量个体中PPARγ2、LPL和αP2基因和基因产物或其他脂肪生成、脂肪生成或脂肪分解基因和基因产物的表达谱来筛选/诊断患有或易于患有肥胖症或相关疾病的受体的方法。本发明还提供筛选新的欧洲橄榄苷类似物的方法。
• ANALOGUES OF OLEUROPEIN AND OLEACEIN AND USES THEREOF
  申请人：Attica Sciences Ltd.

  公开号：US20220110962A1

  公开（公告）日：2022-04-14

  Analogues of oleuropein and oleacein and pharmaceutically acceptable salts thereof and processes for the preparation of these compounds are disclosed. The invention further relates to use of oleuropein and oleacein analogues for the treatment of inflammatory disorders, cardiometabolic disorders, and cancer.

  本发明公开了欧洲橄榄苦苷和欧洲橄榄苦酸及其药学上可接受的盐的类似物，以及制备这些化合物的方法。本发明还涉及使用欧洲橄榄苦苷和欧洲橄榄苦酸类似物治疗炎症性疾病、心脏代谢性疾病和癌症的方法。