The chemical behavior of cyclopropyl-substituted alkynes has been probed using the reaction conditions of ruthenium-catalyzed oxidative CâH/OâH and CâH/NâH bond functionalizations. The oxidative annulations proceeded with complete conservation of all cyclopropane fragments and allowed for the one-step preparation of synthetically useful cyclopropyl-substituted isocoumarins and isoquinolones with high regioselectivities and chemical yields. The connectivities of the key heterocyclic products were unambiguously established by X-ray diffraction analysis.
使用
钌催化的
氧化 C–H/O–H 和 C–H/N–H 键功能化反应条件,对环丙基取代的
炔烃的
化学行为进行了探讨。
氧化环化反应在完全保留所有
环丙烷片段的情况下进行,并允许一步法合成具有高区域选择性和
化学产率的合成有用的环丙基取代异
香豆酸和
异喹啉。关键杂环产物的连接方式通过 X 射线衍射分析得到了明确的确定。