N-Boc-N-methyl-D-serine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Boc-N-methyl-D-serine
• 英文别名: 3-hydroxy-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]propanoic acid
• 化学式: C₉H₁₇NO₅
• 分子量: 219.23
• InChiKey: NJQGIDVCNBZXLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  87.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF
  申请人：AJINOMOTO CO., LTD.

  公开号：US20150051395A1

  公开（公告）日：2015-02-19

  Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.

  提供的是具有特定化学结构的磺酰胺衍生物，在其末端有一个带有苯基或含杂原子的杂环基团作为取代基的磺酰胺基团，以及药用可接受的盐。这些化合物是具有卓越的α4整合素抑制作用的全新化合物。
• Heterocyclic Compound
  申请人：HASHIMOTO Kentaro

  公开号：US20110034469A1

  公开（公告）日：2011-02-10

  The present invention provides a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof. The compound of the present invention shows a strong IAP antagonistic activity.

  本发明提供了一种由下式表示的化合物 其中，每个符号如说明书中所定义，或其盐。本发明的化合物表现出强烈的IAP拮抗活性。
• [EN] PROTEASOME INHIBITORS<br/>[FR] INHIBITEURS DE PROTÉASOME
  申请人：MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V

  公开号：WO2017211818A1

  公开（公告）日：2017-12-14

  The present invention relates to a compound of formula (I), wherein X is C=0, C=S or B-OH; Y is an electrophile and Z is a leaving group, or Y══Z is an electrophile; R1 comprises or consists of (a) (i) a first group binding to a proteolytic site of a proteasome, said first group being bound to X; and (ii) optionally a second group enhancing delivery; or (b) a group binding between subunits β1 and β2 of a proteasome; R2 and R3 are independently selected from H, methyl, methoxy, ethyl, ethenyl, ethinyl and cyano, wherein methyl and ethyl may be substituted with OH or halogen.

  本发明涉及一种化合物，其化学式为（I），其中X为C=0，C=S或B-OH；Y为亲电试剂，Z为脱离基团，或Y══Z为亲电试剂；R1包括或由（a）（i）结合到蛋白酶体的蛋白酶位点的第一基团，所述第一基团与X结合；以及（ii）可选地增强传递的第二基团；或（b）结合到蛋白酶体的亚基β1和β2之间的基团；R2和R3独立地选自H，甲基，甲氧基，乙基，乙烯基，乙炔基和氰基，其中甲基和乙基可以被OH或卤素取代。
• COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
  申请人：AstraZeneca AB

  公开号：US20140206677A1

  公开（公告）日：2014-07-24

  Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed.

  化合物的结构式（I），其药学上可接受的盐，以及利用该结构式（I）化合物治疗细菌感染的用途被披露。
• PYRAZOLO PYRIMIDINE DERIVATIVES
  申请人：MILTZ Wolfgang

  公开号：US20120252778A1

  公开（公告）日：2012-10-04

  The present invention relates to pyrazolo pyrimidine derivatives, to methods of preparing these, to combinations and pharmaceutical composition comprising these, and to their use in the treatment of diseases and disorders which may for example involve autoimmune diseases, angiogenesis, pain, and/or inflammatory diseases.

  本发明涉及吡唑并嘧啶衍生物，涉及制备这些衍生物的方法，涉及包含这些衍生物的组合物和药物组合物，以及它们在治疗可能涉及自身免疫疾病、血管生成、疼痛和/或炎症性疾病的疾病和紊乱中的用途。