20-Hydroxyicosa-5,8,11,14-tetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 20-Hydroxyicosa-5,8,11,14-tetraenoic acid
• 化学式: C₂₀H₃₂O₃
• 分子量: 320.5
• InChiKey: NNDIXBJHNLFJJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Synthesis and use of ω-hydroxylated polyunsaturated fatty acids
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US11001783B2

  公开（公告）日：2021-05-11

  The present invention provides a synthetic chemical method for preparing ω-hydroxylated polyunsaturated fatty acids (PUFAs) including 20-hydroxyeicosatetraenoic acid (20-HETE), 20-hydroxyeicosapentaenoic acid (20-HEPE), and 22-hydroxydocosahexaenoic acid (22-HDoHE) and a method of use thereof for treating cancer and macular degeneration.

  本发明提供了一种制备ω-羟基多不饱和脂肪酸（PUFAs）（包括 20-羟基二十碳四烯酸（20-HETE）、20-羟基二十碳五烯酸（20-HEPE）和 22-羟基二十二碳六烯酸（22-HDoHE））的化学合成方法及其用于治疗癌症和黄斑变性的方法。
• Methods for treating obesity
  申请人：Marshall University Research Corporation

  公开号：US11311600B2

  公开（公告）日：2022-04-26

  Methods for treating obesity are provided and include administering a polypeptide antagonist of a Na/K ATPase/Src receptor complex to a subject in need thereof. Methods for reducing adiposity and adipogenesis are also provided and make use of a polypeptide antagonist of a Na/K ATPase/Src receptor complex to a subject.

  提供了治疗肥胖症的方法，包括向有需要的受试者施用 Na/K ATPase/Src 受体复合物的多肽拮抗剂。还提供了减少肥胖和脂肪生成的方法，并将 Na/K ATPase/Src 受体复合物的多肽拮抗剂用于受试者。
• Compositions and methods relating to hypertension
  申请人：——

  公开号：US20020165208A1

  公开（公告）日：2002-11-07

  This invention relates generally to compositions and methods relating to hypertension. The present invention provides a method of enhancing the activity of Cyp 4A14 by administering an agent thatenhances the activity of Cyp 4A14 as well as a method of inhibiting the activity of Cyp 4A14 by administering an agent that inhibits the activity of Cyp 4A14. Further provided, is a method of enhancing the activity of Cyp 4A12 by administering an agent that enhances the activity of Cyp 4A12 as well as a method of inhibiting the activity of Cyp 4A12 by administering an agent that inhibits the activity of Cyp 4A12. A method of enhancing the activity of Cyp 4A12 by administering an agent that inhibits the activity of Cyp 4A14 is also provided. The invention also provides a method of inhibiting the activity of Cyp 4A12 by administering an agent that enhances the activity of Cyp 4A14. Further provided is a method of enhancing the activity of human Cyp 4A11 by administering an agent that enhances the activity of human Cyp 4A11 as well as a method of inhibiting the activity of human Cyp 4A11 by administering an agent that inhibits the activity of human Cyp 4A11.

  本发明一般涉及与高血压有关的组合物和方法。本发明提供了一种通过施用增强 Cyp 4A14 活性的制剂来增强 Cyp 4A14 活性的方法，以及一种通过施用抑制 Cyp 4A14 活性的制剂来抑制 Cyp 4A14 活性的方法。进一步提供了一种通过施用增强 Cyp 4A12 活性的制剂来增强 Cyp 4A12 活性的方法，以及一种通过施用抑制 Cyp 4A12 活性的制剂来抑制 Cyp 4A12 活性的方法。本发明还提供了一种通过施用抑制 Cyp 4A14 活性的制剂来增强 Cyp 4A12 活性的方法。本发明还提供了一种通过施用增强 Cyp 4A14 活性的制剂来抑制 Cyp 4A12 活性的方法。本发明还提供了一种通过施用增强人Cyp 4A11活性的制剂来增强人Cyp 4A11活性的方法，以及一种通过施用抑制人Cyp 4A11活性的制剂来抑制人Cyp 4A11活性的方法。
• Nanogel networks including polyion polymer fragments and biological agent compositions thereof
  申请人：——

  公开号：US20020136769A1

  公开（公告）日：2002-09-26

  The present invention relates to nanogel networks having at least one cross-linked polyionic polymer fragment and at least one nonionic water-soluble polymer fragment, and compositions thereof, having at least one suitable biological agent.

  本发明涉及具有至少一种交联聚阴离子聚合物片段和至少一种非离子水溶性聚合物片段的纳米凝胶网络及其组合物，其中含有至少一种合适的生物制剂。
• Cross-linked ionic core micelles
  申请人：UNIVERSITY OF NEBRASKA BOARD OF REGENTS

  公开号：US20040228823A1

  公开（公告）日：2004-11-18

  The present invention provides polymer micelles with cross-linked ionic cores as delivery vehicles for therapeutics, diagnostics, nucleic acids, proteins, small molecules and the like. The present invention provides additionally methods of synthesis and uses for such micelles.

  本发明提供具有交联离子核的聚合物胶束，作为治疗、诊断、核酸、蛋白质、小分子等的输送载体。本发明还提供了此类胶束的合成方法和用途。