Tetracosa-9,12,15,18,21-pentaenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Tetracosa-9,12,15,18,21-pentaenoic acid
• 化学式: C₂₄H₃₈O₂
• 分子量: 358.6
• InChiKey: NPTIBOCVSPURCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  26
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] FATTY ACID DERIVATIVES OF CATECHINS AND METHODS OF THEIR USE<br/>[FR] DÉRIVÉS D'ACIDES GRAS DE CATÉCHINES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：GENESIS GROUP INC

  公开号：WO2011123942A1

  公开（公告）日：2011-10-13

  The present disclosure relates to fatty acid derivatives of green tea catechins including epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC), epigallocatechin gallate (EGCG) and their epimers (e.g. catechin, catechin gallate, gallocatechin, gallocatechin gallate) or their mixtures and/or green tea extracts.

  本公开涉及绿茶儿茶素的脂肪酸衍生物，包括表儿茶素（EC）、表儿茶素没食子酸酯（ECG）、表儿茶素（EGC）、表儿茶素没食子酸酯（EGCG）及其外消旋异构体（例如儿茶素、儿茶素没食子酸酯、没食子儿茶素、没食子儿茶素酸酯）或它们的混合物和/或绿茶提取物。
• PHARMACEUTICAL COMPOSITION FOR TRANSCOLONIC ABSORPTION
  申请人：National University Corporation Tokyo Medical and Dental University

  公开号：EP2606910A1

  公开（公告）日：2013-06-26

  The purpose of the present invention is to provide a pharmaceutical composition for transcolonic absorption which is capable of delivering a biologically active substance (in particular, a water-soluble biologically active substance with a high molecular weight) having sites of action in the cell, not by injection, noninvasively and with high specificity into cells in specific tissues. This pharmaceutical composition for transcolonic absorption is characterized by comprising at least (a) and (b) below: (a) a biologically active substance having sites of action in the cell and to which a lipoprotein introduction substance is bonded, and (b) a compound having a large intestine mucous membrane epithelium permeability enhancing effect for the biologically active substance.

  本发明的目的是提供一种用于经溶质吸收的药物组合物，该组合物能够不通过注射， 而以非侵入性和高度特异性的方式将生物活性物质（特别是高分子量的水溶性生物活性物 质）输送到特定组织的细胞中，该生物活性物质在细胞中具有作用位点。这种经溶质吸收的药物组合物的特点是至少包括以下（a）和（b）项：(a) 在细胞中具有作用位点并与脂蛋白导入物质结合的生物活性物质，和 (b) 对生物活性物质具有增强大肠粘膜上皮渗透性作用的化合物。
• METHOD FOR IMPROVING THE RAINFASTNESS OF BENEFICIAL MICROORGANISMS
  申请人：Rhodia Operations

  公开号：EP3954209A1

  公开（公告）日：2022-02-16

  The present invention relates to a composition comprising at least one beneficial microorganism and at least one guar gum. It relates more especially to the use of at least one guar gum as a rainfastness agent in a composition comprising at least one beneficial microorganism.

  本发明涉及一种包含至少一种有益微生物和至少一种瓜尔胶的组合物。 本发明尤其涉及在包含至少一种有益微生物的组合物中使用至少一种瓜尔胶作为防雨剂。
• Nutraceutical composition and methods of use
  申请人：Dacy Tech Party Ltd.

  公开号：US10376550B2

  公开（公告）日：2019-08-13

  A method of modulating inflammation in an organism, which includes administering to an organism a composition including a therapeutic amount of a hydrolyzed extract from the plant Biota orientalis. Several key components of the hydrolyzed extract of Biota orientalis have been identified that have also been shown to have an effect in dramatically reducing inflammatory responses.

  一种调节生物体内炎症的方法，包括向生物体施用一种组合物，该组合物包括治疗量的东方曙红植物水解提取物。已确定东方糙叶榕水解提取物中的几种关键成分也被证明具有显著降低炎症反应的作用。
• ApoE mimetic peptides and higher potency to clear plasma cholesterol
  申请人：UAB RESEARCH FOUNDATION

  公开号：US10653747B2

  公开（公告）日：2020-05-19

  Disclosed are synthetic apolipoprotein E-mimicking peptides, derivatives thereof, and related peptides, which are useful as therapeutic agents for reducing plasma cholesterol; synthetic methods of making the peptides; pharmaceutical compositions comprising the peptides, and methods of treating lipid and metabolic disorders using the disclosed synthetic apolipoprotein E-mimicking peptides and compositions thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本发明公开了可用作降低血浆胆固醇的治疗剂的合成载脂蛋白E模拟肽、其衍生物和相关肽；制造这些肽的合成方法；包含这些肽的药物组合物，以及使用所公开的合成载脂蛋白E模拟肽及其组合物治疗脂质和代谢紊乱的方法。本摘要旨在作为在特定技术领域进行检索的扫描工具，并非对本发明的限制。