β-Methyllanthionin | 767230-59-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: β-Methyllanthionin
• 英文别名: 2-Amino-3-(2-amino-2-carboxyethyl)sulfanylbutanoic acid
• CAS: 767230-59-1
• 化学式: C₇H₁₄N₂O₄S
• 分子量: 222.265
• InChiKey: NSGOABPZARPCFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  152
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (2R,3R)-3-methyl-2-aziridinecarboxylic acid 、 L-半胱氨酸 生成 β-Methyllanthionin
  参考文献：
  名称：

  HATA, YOSHITERU;WATANABE, MASAMICHI, TETRAHEDRON, 43,(1987) N 17, 3881-3888

  摘要：

  DOI：

文献信息

• Differentially protected orthogonal lanthionine technology
  申请人：Hillman D. Jeffrey

  公开号：US20070037963A1

  公开（公告）日：2007-02-15

  The present invention provides a method of synthesizing an intramolecularly bridged polypeptide comprising at least one intramolecular bridge. The present invention further provides a method of synthesizing an intramolecularly bridged polypeptide comprising two intramolecular bridges, wherein the two intramolecular bridges form two overlapping ring, two rings in series, or two embedded rings. The present invention also provides methods for synthesizing lantibiotics, including Nisin A. Additionally, the invention provides intramolecularly bridged polypeptides synthesized by the methods disclosed herein and differentially protected orthogonal lanthionines.

  本发明提供了一种合成至少含有一个分子内桥连接的多肽的方法。本发明还提供了一种合成含有两个分子内桥连接的多肽的方法，其中这两个分子内桥连接形成两个重叠环、两个串联环或两个嵌套环。本发明还提供了一种合成乳酸抗生素，包括Nisin A的方法。此外，本发明提供了通过本文所披露的方法合成的分子内桥连接的多肽和差异保护的正交乳酸硫氨酸。
• DIFFERENTIALLY PROTECTED ORTHOGONAL LANTHIONINE TECHNOLOGY
  申请人：Kirichenko Kostyantyn

  公开号：US20090215985A1

  公开（公告）日：2009-08-27

  The present invention provides a method of synthesizing an intramolecularly bridged polypeptide comprising at least one intramolecular bridge. The present invention further provides a method of synthesizing an intramolecularly bridged polypeptide comprising two intramolecular bridges, wherein the two intramolecular bridges form two overlapping ring, two rings in series, or two embedded rings. The present invention also provides methods for synthesizing lantibiotics, including Nisin A. Additionally, the invention provides intramolecularly bridged polypeptides synthesized by the methods disclosed herein and differentially protected orthogonal lanthionines.

  本发明提供了一种合成至少包含一个分子内桥的分子内桥肽的方法。本发明还提供了一种合成包含两个分子内桥的分子内桥肽的方法，其中两个分子内桥形成两个重叠的环、两个串联的环或两个嵌入的环。本发明还提供了合成乳酸菌素的方法，包括Nisin A。此外，本发明还提供了通过本文所述方法合成的分子内桥肽和差异保护正交兰西奥宁的方法。
• Isolation and purification of lantibiotics
  申请人：Dr. Karl Thomae GmbH

  公开号：EP0508371A1

  公开（公告）日：1992-10-14

  A process for isolating and purifying a lantibiotic from a fermentation broth using a styrene-divinyl-copolymerisate matrix, a strong cation exchanger, means for hydrophobic interaction chromatography and preferably a weak anion exchanger.

  一种利用苯乙烯-二乙烯基-共聚物基质、强阳离子交换剂、疏水作用色谱法和最好是弱阴离子交换剂从发酵液中分离和纯化兰特生物菌的工艺。
• A method for selecting a gene involved in nisin resistance in bacteria
  申请人：Stichting voor de Technische Wetenschappen

  公开号：EP1609872A1

  公开（公告）日：2005-12-28

  The present invention discloses a method for selecting a gene involved with nisin-resistance in a species of bacteria comprising providing candidate genes that are differentially expressed in nisin-resistant and sensitive strains of said species and selecting from said candidate genes at least one gene that results in an altered nisin-resistance phenotype in a strain of said species, when expression of said gene is altered. The invention further provides a bacterial strain obtained by the method of the invention, and a method for fermenting dairy products with said bacterial strain. The invention also discloses cheese produced by fermentation according to the invention.

  本发明公开了一种在细菌物种中选择参与尼生素抗性基因的方法，包括提供在所述物种的尼生素抗性和敏感菌株中不同表达的候选基因，并从所述候选基因中选择至少一个基因，当所述基因的表达发生改变时，该基因会导致所述物种的菌株的尼生素抗性表型发生改变。本发明进一步提供了通过本发明方法获得的细菌菌株，以及用所述细菌菌株发酵乳制品的方法。本发明还公开了根据本发明发酵生产的奶酪。
• VARIANT NISIN PEPTIDES
  申请人：University College Cork-National University of Ireland, Cork

  公开号：EP3822285A1

  公开（公告）日：2021-05-19

  The invention relates to a variant nisin peptide, wherein the variant nisin peptide is a modified variant of wild-type nisin, wherein the modification comprises or consists of an amino acid residue modification selected from: i) M17Q or M17A; ii) T2L; and iii) one set of modified hinge residues selected from a) N20H and M21T, b) N20V, M21G, and K22A, c) N20V, M21G, and K22V or d) N20V, M21G, and K22T; or v) combinations of modifications i), ii), and iii), and related medical uses and products comprising such nisin peptides.

  本发明涉及一种变体尼生素肽，其中所述变体尼生素肽是野生型尼生素的修饰变体，所述修饰包括或由选自以下的氨基酸残基修饰组成：i)M17Q或M17A；ii)T2L；和iii)一组选自a)N20H和M21T、b)N20V、M21G和K22A、c)N20V、M21G和K22V或d)N20V、M21G和K22T的修饰铰链残基；或v)修饰i)、ii)和iii)的组合，以及包含这种尼生素肽的相关医疗用途和产品。