6'-hydroxy-justicidin B | 145726-39-2

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 芳基萘木脂素
• 英文名称: 6'-hydroxy-justicidin B
• 英文别名: 9-(6-hydroxy-benzo[1,3]dioxol-5-yl)-6,7-dimethoxy-3H-naphtho[2,3-c]furan-1-one；9-(6-hydroxybenzo[d][1,3]dioxol-5-yl)-6,7-dimethoxynaphtho[2,3-c]furan-1(3Η)-one；Justicidin H；4-(6-hydroxy-1,3-benzodioxol-5-yl)-6,7-dimethoxy-1H-benzo[f][2]benzofuran-3-one
• CAS: 145726-39-2
• 化学式: C₂₁H₁₆O₇
• 分子量: 380.354
• InChiKey: NXDFXQJRGLAEKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  83.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6'-hydroxy-justicidin B 在 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以81%的产率得到1-(6-hydroxybenzo[d][1,3]dioxol-5-yl)-3-(hydroxymethyl)-6,7-dimethoxy-2-naphthoate sodium
  参考文献：
  名称：

  [EN] NOVEL DIALKOXYNAPHTHO[2,3-C]FURAN-1(3H)-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASE OR SARS-COV-2 INFECTION DISEASE, COMPRISING SAME
  [FR] NOUVEAUX DÉRIVÉS DE DIALCOXYNAPHTO[2,3-C]FURAN-1 (3H)-ONE ET COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT D'UNE MALADIE RESPIRATOIRE OU D'UNE MALADIE À INFECTION PAR SARS-COV-2 LES COMPRENANT
  [KO] 신규한 디알콕시나프토[2,3-C]퓨란-1(3H)-온 유도체 및 이를 포함하는 호흡기 질환 또는 SARS-COV-2 감염 질환의 예방 또는 치료용 약제학적 조성물

  摘要：

  본 발명은 하기 화학식 1의 화합물, 하기 화학식 3의 화합물, 하기 [212] 화합물, [224] 화합물, 또는 [228] 화합물; 이의 약제학적으로 허용 가능한 염; 이의 입체 이성질체; 이의 수화물; 또는 이의 용매화물, 및 이를 포함하는 약제학적 조성물을 제공한다. 상기 약제학적 조성물은 우수한 항바이러스 효능을 가지므로 SARS-CoV-2와 같은 바이러스 감염 질환의 예방 또는 치료 효과를 가지며, IL-5 발현 억제 효과를 보이므로 호흡기 질환 또는 알레르기성 질환의 예방 또는 치료 효과를 가진다.

  公开号：

  WO2022208382A1
• 作为产物：
  描述：

  6,7-dimethoxy-9-(6-methoxymethoxy-benzo[1,3]dioxol-5-yl)-3H-naphtho[2,3-c]furan-1-one 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 12.0h， 以72.5%的产率得到6'-hydroxy-justicidin B
  参考文献：
  名称：

  [EN] PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CORONAVIRUS INFECTIOUS DISEASES
  [FR] COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES INFECTIEUSES À CORONAVIRUS
  [KO] 코로나바이러스 감염 질환의 예방 또는 치료용 약학적 조성물

  摘要：

  本发明涉及一种预防或治疗冠状病毒感染疾病的药物组合物，或用于预防或改善冠状病毒感染疾病的食品组合物，或用于抗冠状病毒的组合物，其有效成分包括鼠尾草（Justicia procumbens）有机溶剂提取物，Justicidin-A，Justicidin-B或6'羟基Justicidin-B。由于这些组合物包括优秀的冠状病毒抑制效果的鼠尾草无水乙醇提取物和Justicidin-A，Justicidin-B或6'羟基Justicidin-B，因此可以有效地预防，治疗或改善冠状病毒感染疾病。（其中SARS-CoV-2在上述冠状病毒中除外）

  公开号：

  WO2022085806A1

文献信息

• KR2022/51628
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DISEASES CAUSED BY SARS-COV-2<br/>[FR] COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES CAUSÉES PAR LE SARS-COV-2
  申请人：DONG WHA PHARM CO LTD

  公开号：WO2021206309A1

  公开（公告）日：2021-10-14

  The present invention relates to a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising an organic solvent extract of Justicia procumbens as an effective ingredient, a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising justicidin-A as an effective ingredient, a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising justicidin-B as an effective ingredient, or a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising 6' hydroxyl justicidin-B as an effective ingredient, and a food composition thereof for preventing or ameliorating COVID-19 diseases. According to the present invention, an anhydrous ethanol extract of Justicia procumbens, justicidin-A, justicidin-B, and 6' hydroxyl justicidin-B effectively inhibit SARS-CoV-2 virus, and thus may effectively prevent, treat, or ameliorate diseases caused by SARS-CoV-2 virus.