4-{[4'-(3-chloropropoxy)[1,1'-biphenyl]-4-yl]carbonyl}morpholine | 372514-07-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-{[4'-(3-chloropropoxy)[1,1'-biphenyl]-4-yl]carbonyl}morpholine
• 英文别名: [4-[4-(3-chloropropoxy)phenyl]phenyl]-morpholin-4-ylmethanone
• CAS: 372514-07-3
• 化学式: C₂₀H₂₂ClNO₃
• 分子量: 359.853
• InChiKey: DBCPQZINGWNFEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3R)-(+)-3-(二甲氨基)吡咯烷 、 4-{[4'-(3-chloropropoxy)[1,1'-biphenyl]-4-yl]carbonyl}morpholine 在 potassium carbonate 、 potassium iodide 作用下， 以 丁酮 为溶剂， 反应 72.0h， 生成 [4-[4-[3-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]propoxy]phenyl]phenyl]-morpholin-4-ylmethanone
  参考文献：
  名称：

  Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists

  摘要：

  Novel 4'-[(NRIR2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at histamine H(3)receptors. Most compounds were highly potent and selective for human and rat H-3 receptors and selected examples such as A-349821 showed functional antagonism of H3 receptors in vitro and in a mouse dipsogenia model. (C) 2003 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(03)00118-5
• 作为产物：
  描述：

  Methyl 4'-(3-chloropropoxy)[1,1'-biphenyl]-4-carboxylate 在 lithium hydroxide 、 氯化亚砜 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 4-{[4'-(3-chloropropoxy)[1,1'-biphenyl]-4-yl]carbonyl}morpholine
  参考文献：
  名称：

  Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists

  摘要：

  Novel 4'-[(NRIR2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at histamine H(3)receptors. Most compounds were highly potent and selective for human and rat H-3 receptors and selected examples such as A-349821 showed functional antagonism of H3 receptors in vitro and in a mouse dipsogenia model. (C) 2003 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(03)00118-5

文献信息

• Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
  申请人：——

  公开号：US20020111340A1

  公开（公告）日：2002-08-15

  Compounds of formula (I) 1 are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands.

  化学式为(I)1的化合物可用于治疗由组胺-3受体配体预防或改善的疾病或症状。
• US6316475B1
  申请人：——

  公开号：US6316475B1

  公开（公告）日：2001-11-13
• Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists
  作者：Ramin Faghih、Wesley Dwight、Jia Bao Pan、Gerard B. Fox、Kathy M. Krueger、Timothy A. Esbenshade、Jill M. McVey、Kennan Marsh、Youssef L. Bennani、Arthur A. Hancock

  DOI：10.1016/s0960-894x(03)00118-5

  日期：2003.4

  Novel 4'-[(NRIR2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at histamine H(3)receptors. Most compounds were highly potent and selective for human and rat H-3 receptors and selected examples such as A-349821 showed functional antagonism of H3 receptors in vitro and in a mouse dipsogenia model. (C) 2003 Published by Elsevier Science Ltd.