spectomycin A2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: spectomycin A2
• 英文别名: Spectomycin A2；3-methoxy-3-(2,5,10-trihydroxy-2-methyl-4-oxo-1,3-dihydroanthracen-1-yl)prop-2-enoic acid
• 化学式: C₁₉H₁₈O₇
• 分子量: 358.348
• InChiKey: OBCPKCVHPDMGIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  spectomycin A2 在 氢溴酸 、 溶剂黄146 作用下， 以5.6 mg的产率得到3-(5,10-Dihydroxy-2-methyl-4-oxo-3,4-dihydro-anthracen-1-yl)-3-oxo-propionic acid
  参考文献：
  名称：

  Spectomycins, new antibacterial compounds produced by Streptomyces spectabilis: isolation, structures, and biosynthesis.

  摘要：

  Three new tetrahydroanthracene antibiotics have been isolated from modified culture broths of Streptomyces spectabilis. The new compounds, spectomycins Al, A2 and Bl, exist as monomeric (C20H20O7, Al; C19H18O7, A2) and as symmetrical dimeric (C38H34O14; Bl) forms. Only spectomycin Bl has moderate activity against Gram-positive microorganisms. We report here the structure elucidation and biosynthetic origin of these compounds.

  DOI：

  10.7164/antibiotics.47.1425