Methyl 4'-(3-chloropropoxy)[1,1'-biphenyl]-4-carboxylate | 372514-04-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 4'-(3-chloropropoxy)[1,1'-biphenyl]-4-carboxylate
• 英文别名: methyl 4-[4-(3-chloropropoxy)phenyl]benzoate
• CAS: 372514-04-0
• 化学式: C₁₇H₁₇ClO₃
• 分子量: 304.773
• InChiKey: NMJVWKUUDAXCFV-UHFFFAOYSA-N

物化性质

• 沸点：
  449.6±35.0 °C(Predicted)
• 密度：
  1.167±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl 4'-(3-chloropropoxy)[1,1'-biphenyl]-4-carboxylate 在 lithium hydroxide 、 氯化亚砜 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 4-{[4'-(3-chloropropoxy)[1,1'-biphenyl]-4-yl]carbonyl}morpholine
  参考文献：
  名称：

  Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists

  摘要：

  Novel 4'-[(NRIR2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at histamine H(3)receptors. Most compounds were highly potent and selective for human and rat H-3 receptors and selected examples such as A-349821 showed functional antagonism of H3 receptors in vitro and in a mouse dipsogenia model. (C) 2003 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(03)00118-5
• 作为产物：
  描述：

  4-羟基-[1,1-联苯]-4-羧酸甲酯 、 1-溴-3-氯丙烷 在 potassium carbonate 作用下， 以 丁酮 为溶剂， 反应 24.0h， 以100%的产率得到Methyl 4'-(3-chloropropoxy)[1,1'-biphenyl]-4-carboxylate
  参考文献：
  名称：

  Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists

  摘要：

  Novel 4'-[(NRIR2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at histamine H(3)receptors. Most compounds were highly potent and selective for human and rat H-3 receptors and selected examples such as A-349821 showed functional antagonism of H3 receptors in vitro and in a mouse dipsogenia model. (C) 2003 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(03)00118-5

文献信息

• Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
  申请人：Abbott Laboratories

  公开号：US06316475B1

  公开（公告）日：2001-11-13

  Compounds of formula (I) are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands.

  式(I)的化合物可用于治疗由组胺-3受体配体预防或改善的疾病或症状。
• US6316475B1
  申请人：——

  公开号：US6316475B1

  公开（公告）日：2001-11-13
• [EN] AMINOALKOXYBIPHENYL CARBOXAMIDES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS<br/>[FR] AMINOALCOXYBIPHENYL CARBOXAMIDES UTILES EN TANT QUE LIGANDS DU RECEPTEUR D'HISTAMINE-3 ET APPLICATIONS THERAPEUTIQUES DE CES DERNIERS
  申请人：ABBOTT LAB

  公开号：WO2002040461A2

  公开（公告）日：2002-05-23

  Compounds of formula (I) are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands.
• Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists
  作者：Ramin Faghih、Wesley Dwight、Jia Bao Pan、Gerard B. Fox、Kathy M. Krueger、Timothy A. Esbenshade、Jill M. McVey、Kennan Marsh、Youssef L. Bennani、Arthur A. Hancock

  DOI：10.1016/s0960-894x(03)00118-5

  日期：2003.4

  Novel 4'-[(NRIR2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at histamine H(3)receptors. Most compounds were highly potent and selective for human and rat H-3 receptors and selected examples such as A-349821 showed functional antagonism of H3 receptors in vitro and in a mouse dipsogenia model. (C) 2003 Published by Elsevier Science Ltd.