S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] hexanethioate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] hexanethioate
• 化学式: C₂₇H₄₆N₇O₁₇P₃S
• 分子量: 865.7
• InChiKey: OEXFMSFODMQEPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  55
• 可旋转键数：
  24
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  389
• 氢给体数：
  9
• 氢受体数：
  22

文献信息

• LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS
  申请人：Tang Yi

  公开号：US20120190038A1

  公开（公告）日：2012-07-26

  The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities currently producing lovastatin can be converted to producing simvastatin and related compounds with minimal modifications.
• METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS
  申请人：Tang Yi

  公开号：US20120315680A1

  公开（公告）日：2012-12-13

  The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
• VARIANT LovD POLYPEPTIDE
  申请人：The Regents of the University of California

  公开号：US20150218531A1

  公开（公告）日：2015-08-06

  The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities currently producing lovastatin can be converted to producing simvastatin and related compounds with minimal modifications.
• METHOD FOR PRODUCING METHACRYLIC ACID ESTER AND NOVEL METHACRYLIC ACID ESTER SYNTHETASE
  申请人：PUBLIC UNIVERSITY CORPORATION TOYAMA PREFECTURAL UNIVERSITY

  公开号：US20170022525A1

  公开（公告）日：2017-01-26

  Provided is a method for producing a methacrylic acid ester using a biocatalyst, said method comprising a step of reacting an alcohol or a phenol with methacrylyl-CoA in the presence of an alcohol acyltransferase originated from a plant selected from the group consisting of a plant belonging to the genus Osmanthus, a plant belonging to the genus Vitis, a plant belonging to the genus Citrus, a plant belonging to the genus Durio, a plant belonging to the genus Magnolia and a plant belonging to the genus Chamaemelum to thereby synthesize the methacrylic acid ester.
• US8951754B2
  申请人：——

  公开号：US8951754B2

  公开（公告）日：2015-02-10