2-(2-Chinolyl-6,8-disulfonsaeure)-1,3-indandion | 94803-32-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-(2-Chinolyl-6,8-disulfonsaeure)-1,3-indandion
• 英文别名: 2-(1,3-dioxo-indan-2-yl)-quinoline-6,8-disulfonic acid；2-(1,3-Dioxo-2,3-dihydro-1h-inden-2-yl)quinoline-6,8-disulfonic acid；2-(1,3-dioxoinden-2-yl)quinoline-6,8-disulfonic acid
• CAS: 94803-32-4
• 化学式: C₁₈H₁₁NO₈S₂
• 分子量: 433.419
• InChiKey: OESPFRYVCUTRKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  173
• 氢给体数：
  2
• 氢受体数：
  9

ADMET

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、球囊阀面罩设备或口袋面罩，按训练操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果患者呕吐，让患者向前倾或将其置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗救助。 /毒物A和B/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道（如有需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。预防癫痫发作，如有必要，进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用温水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于昏迷、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。考虑使用药物治疗肺水肿……。对于严重的支气管痉挛，考虑给予β激动剂，如沙丁胺醇……。监测心率和必要时治疗心律失常……。开始静脉输注D5W /SRP: "保持开放"，最小流量/。如果出现低血容量的迹象，使用0.9%的生理盐水（NS）或乳酸林格氏液。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象……。使用地西泮或劳拉西泮治疗癫痫……。使用丙美卡因氢氯化物协助眼部冲洗……。 /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

人类暴露研究/重复侮辱贴片测试喹啉染料，D & C Yellow No. 10（酸黄No. 3）和D & C Yellow No. 11（溶剂黄No. 33）表明，前者的浓度高达1000 ppm没有诱导迟发型接触超敏反应，而D & C Yellow No. 11的20 ppm和10 ppm浓度在人类志愿者小组成员中诱导了迟发型超敏反应。这种染料的5 ppm测试没有明确导致超敏反应。两名使用含有D & C Yellow No. 11的肥皂条出现过敏性反应的人在使用这种染料被替换为D & C Yellow No. 10的肥皂条时没有反应。

/HUMAN EXPOSURE STUDIES/ Repeat insult patch testing of the quinoline dyes, D & C Yellow No. 10 (Acid Yellow No. 3) and D & C Yellow No. 11 (Solvent Yellow No. 33) demonstrated that concentrations as high as 1,000 ppm of the former induced no delayed contact hypersensitivity, whereas, concentrations of 20 ppm and 10 ppm of D & C Yellow No. 11 induced delayed hypersensitivity reactions in human volunteer panelists. No definitive hypersensitivity resulted from testing with 5 ppm of this dye. 2 persons who had been demonstrated to have reacted allergically to the use of a soap bar that contained D & C Yellow No. 11 did not react to the ad libitum use of a soap bar in which this dye was replaced with D & C Yellow No. 10.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

/HUMAN EXPOSURE STUDIES/ 人类暴露研究/ 喹啉染料D&C黄色11号被添加到标准测试系列中。在用1%聚乙二醇测试的88名患者中，有4名患者出现了无法解释的阳性测试反应。一名患者在14天后出现了“爆发”反应。在再次挑战时，他对稀释至0.00001%的浓度产生了反应。与化学上相关的常用食品色素喹啉黄（E 104）同时发生反应，表明存在交叉敏感性。

/HUMAN EXPOSURE STUDIES/ The quinoline color D & C Yellow No. 11 was added to a standard test series. Of 88 patients tested with 1% in PEG, four showed unexplained positive test reactions. One patient had a "flare-up" reaction after 14 days. At rechallenge he reacted to a dilution down to 0.00001%. Simultaneous reaction with the chemically related commonly used food color Quinoline Yellow (E 104) suggests cross-sensitivity.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

黄色喹啉在 rats 中的摄取、命运和排泄进行了研究。在孤立灌注的肝脏中，70% 的剂量在 3 小时内排入胆汁中。在麻醉动物静脉注射后得到类似结果。当通过灌胃给药时，4-5 小时内只有大约 1% 在胆汁和尿液中排泄。口服给大鼠的黄色喹啉被定量排泄，主要排泄途径为粪便。大鼠从胃肠道吸收的黄色喹啉非常少。没有发现代谢的证据。

The uptake, fate and excretion of quinoline yellow, a coloring in sweets and soft drinks, in the rat were studied. In the isolated perfused liver, 70% of the dose was excreted into the bile within 3 hr. Similar results were obtained after i.v. injection into anesthetized animals. When given by gavage, only approximately 1% was excreted in bile and urine within 4-5 hr. Quinoline yellow administered orally to rats was quantitatively excreted, the excretion being mainly fecal. ... Very little quinoline yellow is absorbed from the gastrointestinal tract of the rat. No evidence of metabolism was obtained.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

喹啉黄在大鼠和狗的胃肠道的吸收程度很小，大部分口服给药剂量以原形被排泄。

Quinoline Yellow is absorbed from the gastro-intestinal tract to only a small extent in rats and dogs, and most of an orally administered dose is excreted unchanged.

来源:Hazardous Substances Data Bank (HSDB)

文献信息

• Leave-in color conditioner
  申请人：Pollack George

  公开号：US20050198746A1

  公开（公告）日：2005-09-15

  The invention is directed to novel hair dye compositions, novel leave-in conditioners, and novel leave-in conditioners with a hair coloring effect. Hair dye compositions, leave-in conditioners, and leave-in conditioners with hair coloring effect may include a styrene/vinylpyrrolidone copolymer emulsion.

  本发明涉及新型染发剂组合物、新型留香护发素以及具有染发效果的新型留香护发素。染发剂组合物、留香护发素和具有染发效果的留香护发素可能包括苯乙烯/吡咯烷酮共聚物乳液。
• Methods and systems for extracting reduced oxalic acid protein from aquatic species and compositions thereof
  申请人：Parabel Nutrition, Inc.

  公开号：US11325941B2

  公开（公告）日：2022-05-10

  The present disclosure relates, according to some embodiments, to methods and systems for purifying proteins having a reduced oxalic acid content from aquatic species and compositions thereof.

  根据一些实施例，本公开涉及从水生物种中纯化草酸含量降低的蛋白质及其组合物的方法和系统。
• METHODS AND SYSTEMS FOR EXTRACTING REDUCED OXALIC ACID PROTEIN FROM AQUATIC SPECIES AND COMPOSITIONS THEREOF
  申请人：Parabel Ltd.

  公开号：EP3334748A1

  公开（公告）日：2018-06-20
• ANIONIC DYE OR BRIGHTENER BEARING AN AMMONIUM OR PHOSPHONIUM COUNTERION, DYE COMPOSITION COMPRISING THEM AND PROCESS FOR DYEING KERATIN FIBRES USING THESE DYES
  申请人：L'OREAL

  公开号：US20150113742A1

  公开（公告）日：2015-04-30

  The invention relates to the dyeing of human keratin fibres, especially the hair, using anionic direct dyes bearing a particular ammonium or phosphonium counterion of formula (Ia) and/or optical brighteners of formula (Ib) Col (−) m [X + ] n (Ia) Azu (−) m [X + ] n (Ib) in which formulae (Ia) and (Ib): Azu/Col (−) m, R 1 , R 2 , R 3 , R 4 , m and n are as defined in the description. The invention relates to a dye composition comprising an anionic compound of formula (Ia) and/or (Ib), and to a process for dyeing keratin fibres such as the hair, using the said composition. Similarly, the invention relates to novel anionic compounds of formula (Ia) or (Ib) and to the uses thereof for dyeing keratin fibres. This composition makes it possible to obtain chromatic, powerful and particularly fast coloration on keratin fibres and particularly lightening coloration via an optical effect on dark hair.
• US4398916A
  申请人：——

  公开号：US4398916A

  公开（公告）日：1983-08-16