Lincomycin,

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Lincomycin,
• 英文别名: Lincomycin A；N-[2-hydroxy-1-(3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl)propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
• 化学式: C₁₈H₃₄N₂O₆S
• 分子量: 406.544
• InChiKey: OJMMVQQUTAEWLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  148
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Small molecules active against gram-negative bacteria
  申请人：The Board of Trustees of the University of Illinois

  公开号：US10995097B2

  公开（公告）日：2021-05-04

  Disclosed are compounds that accumulate in Gram-negative bacteria. Also disclosed are method of antimicrobial treatment using the compounds.

  公开了可在革兰氏阴性细菌中蓄积的化合物。还公开了使用这些化合物进行抗菌治疗的方法。
• Compound antibacterial drugs comprising n-acetyl-d-glucosamine
  申请人：Xu Qiwang

  公开号：US20070191291A1

  公开（公告）日：2007-08-16

  The use of the combination of N-acetyl-D-glucosamine and antibiotics for the preparation of antibacterial drugs is disclosed. In the therapies of infections with antibiotics, the pathogens may be changed into slender shaped forms called cryptic growth cells (CGCs), CGCs can colonize and thereby physiological drug resistance arises. In the meantime, normal bacteria colonies in the body may be also changed into CGCs upon administration of antibiotics. These changes result in complications after the therapies, such as disorder of bacteria colonies in the body, disorder of GI functions and other chronic diseases. The combination of antibiotics and N-acetyl-D-aminoglycosamine can prevent of CGC, and the complications after antibiotics therapy.
• ELISA KIT FOR DETECTING LINCOMYCIN
  申请人：He Fangyang

  公开号：US20110111440A1

  公开（公告）日：2011-05-12

  The present invention provides an ELISA kit for detecting lincomycin comprising a coating antigen and an enzyme labeled reagent, wherein the coating antigen is selected from the group consisting of a lincomycin hapten-carrier protein conjugate, a lincomycin antibody and a lincomycin anti-antibody; when the coating antigen is the lincomycin hapten-carrier protein conjugate, the enzyme labeled reagent is an enzyme-labeled lincomycin anti-antibody; when the coating antigen is the lincomycin antibody, the enzyme labeled reagent is an enzyme-labeled lincomycin hapten-carrier protein conjugate; and when the coating antigen is the lincomycin anti-antibody, the enzyme labeled reagent is an enzyme-labeled lincomycin hapten-carrier protein conjugate; and the lincomycin hapten is obtained through the condensation reaction between lincomycin and succinic anhydride. The ELISA kit according to the present invention can be used for detecting the content of lincomycin remained in a sample such as an animal tissue (muscle, liver), honey, etc.
• SMALL MOLECULES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20190135821A1

  公开（公告）日：2019-05-09

  Disclosed are compounds that accumulate in Gram-negative bacteria. Also disclosed are method of antimicrobial treatment using the compounds.
• US8507214B2
  申请人：——

  公开号：US8507214B2

  公开（公告）日：2013-08-13

表征谱图