4-hydroxy-benzoic acid menthyl ester | 146367-00-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-hydroxy-benzoic acid menthyl ester
• 英文别名: 4-Hydroxy-benzoesaeure-menthylester；(5-Methyl-2-propan-2-ylcyclohexyl) 4-hydroxybenzoate
• CAS: 146367-00-2
• 化学式: C₁₇H₂₄O₃
• 分子量: 276.376
• InChiKey: XWKSYRJGOJRDIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对羟基苯甲酰氯 、 L-薄荷醇 在 吡啶 作用下， 生成 4-hydroxy-benzoic acid menthyl ester
  参考文献：
  名称：

  Intubation avec le stylet lumineux Trachlight™: un aperçu des connaissances actuelles

  摘要：

  Purpose: About 1% to 3% of laryngoscopic intubations can be difficult or impossible. Light-guided intubation has been proven to be an effective, safe, and simple technique. This article reviews current knowledge about the newer version lightwand: the Trachlight (TM) (TL).Source: To determine its clinical utility and limitations, we reviewed the current literature (book and journal articles) on the TL since its introduction in 1995.Principal findings: TL has been shown to be useful both in oral and nasal intubation for patients with difficult airways, It may also be useful in "emergency" situations or when direct laryngoscopy or fiberoptic endoscopy is not effective, such as with patients who have copious secretions or blood in the oropharynx. TL can also be used for tracheal intubation in conjunction with other devices (laryngeal mask airway -LMA-, intubating LMA, direct laryngoscopy). However, TL should be avoided in patients with tumours, infections, trauma or foreign bodies in the upper airway.Conclusions: Based on the clinical reports available, the TL has proven to be a useful option for tracheal intubation. In addition, the device can also be used together with other intubating devices, such as the intubating LMA and the laryngoscope, to improve intubating success rates. A clear understanding of the principle of transillumination of the TL, and an appreciation of its indications, contraindications, and limitations, will improve the effectiveness of the device as well as reducing the likelihood of complications. Finally, regular practice with the TL with routine surgical patients requiring tracheal intubation will further improve intubation success rates.

  DOI：

  10.1007/bf03016838

文献信息

• Dermatological cosmetic composition comprising vitamin K1 oxide
  申请人：Auriga International S.A.

  公开号：EP1442738A1

  公开（公告）日：2004-08-04

  The present invention is related to a dermatological cosmetic composition comprising vitamin K1 oxide and its use for topical dermatological applications on skin.

  本发明涉及一种包含维生素 K1 氧化物的皮肤美容组合物及其在皮肤局部应用中的使用。
• Polymerizable menthol derivative
  申请人：Chisso Corporation

  公开号：EP2060617A1

  公开（公告）日：2009-05-20

  The invention includes compounds represented by Formula (1) : wherein R represents hydrogen or methyl; A represents alkylene having from 1 to 12 carbon atoms, wherein in the alkylene, arbitrary -CH2- may be replaced by -O-, -S-, -CH=CH-, -CO-, -COO- or -OCO-; X and Y each independently represent an aromatic ring or a cyclohexane ring, wherein in the rings, arbitrary hydrogen may be replaced by alkyl having from 1 to 3 carbon atoms; Z independently represents a single bond, -O-, -S-, -COO-, -OCO-, -CON(R1)- or -N(R1)CO-, wherein R1 represents hydrogen or methyl; and m represents an integer of from 0 to 3.

  本发明包括由式 (1) : 其中 R 代表氢或甲基； A 代表具有 1 至 12 个碳原子的亚烷基，其中在亚烷基中，任意的 -CH2- 可被 -O-、-S-、-CH=CH-、-CO-、-COO- 或 -OCO- 所取代； X 和 Y 各自独立地代表芳香环或环己烷环，其中在环中，任意氢可被具有 1 至 3 个碳原子的烷基取代； Z 独立地代表单键、-O-、-S-、-COO-、-OCO-、-CON(R1)- 或-N(R1)CO-，其中 R1 代表氢或甲基；以及 m 代表 0 至 3 的整数。
• Use of a composition comprising vitamin k1 oxide or a derivative thereof for the treatment and/or the prevention of mammal dermatological lesions
  申请人：Marchal Alfred

  公开号：US20060154983A1

  公开（公告）日：2006-07-13

  The present invention is related to the use of a composition having an adequate pharmaceutical or cosmetic carrier or diluent and a sufficient amount of vitamin K1 oxide or its derivative for the treatment and/or the prevention of mammal dermatological lesions. The present invention is also related to a cosmetic composition having an adequate cosmetic carrier, phospholipids and vitamin K1 oxide or its derivative.

  本发明涉及一种组合物的用途，该组合物具有适当的药物或化妆品载体或稀释剂和足量的维生素 K1 氧化物或其衍生物，可用于治疗和/或预防哺乳动物皮肤病。本发明还涉及一种具有适当化妆品载体、磷脂和维生素 K1 氧化物或其衍生物的化妆品组合物。
• USE OF A COMPOSITION COMPRISING VITAMIN K1 OXIDE OR A DERIVATIVE THEREOF FOR THE TREATMENT AND/OR THE PREVENTION OF MAMMAL DERMATOLOGICAL LESIONS
  申请人：Auriga International S.A.

  公开号：EP1594456A1

  公开（公告）日：2005-11-16
• ANTIMICROBIAL CATHELICIDIN PEPTIDES
  申请人：Kansas State University Research Foundation

  公开号：EP1966235A2

  公开（公告）日：2008-09-10