3,7-diaminoheptanoic Acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,7-diaminoheptanoic Acid
• 化学式: C₇H₁₆N₂O₂
• 分子量: 160.21
• InChiKey: PJDINCOFOROBQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Modified antibiotic peptides having variable systemic release
  申请人：Hoffmann Ralf

  公开号：US20140309161A1

  公开（公告）日：2014-10-16

  The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all.

  该发明涉及改性抗生素肽，特别是蜜蜂素和肿瘤素的衍生物，优选具有增强稳定性、减少免疫反应和改善药代动力学的特性。在该发明中，肽抗生素通过具有聚合物聚乙二醇（PEG）的连接剂进行可逆保护。肽连接剂包含一种识别序列，用于类胰蛋白酶样血清蛋白酶。在蜜蜂素衍生物中，连接剂和PEG与侧链结合。在血清中，连接剂被血清蛋白酶切割，PEG被分离。释放的肽仍然含有连接剂的残留物，这些残留物仍然与侧链中的氨基团结合。令人惊讶的是，连接剂的剩余残留物仅轻微或根本不影响抗微生物肽的活性。
• MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID
  申请人：Burk Mark J.

  公开号：US20120282661A1

  公开（公告）日：2012-11-08

  The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

  本发明提供了一种非自然存在的微生物有6-氨基己酸、己内酰胺、六亚甲基二胺或丙酮酸途径。该微生物含有至少一种外源核酸，编码相应的6-氨基己酸、己内酰胺、六亚甲基二胺或丙酮酸途径中的酶。本发明还提供了一种生产6-氨基己酸、己内酰胺、六亚甲基二胺或丙酮酸的方法。该方法可以包括培养6-氨基己酸、己内酰胺或六亚甲基二胺产生微生物，其中微生物在适当的条件下表达至少一种外源核酸编码的6-氨基己酸、己内酰胺、六亚甲基二胺或丙酮酸途径酶，以产生相应的产物，持续一定的时间。
• MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF HEXAMETHYLENEDIAMINE
  申请人：Genomatica, Inc.

  公开号：EP3611254A1

  公开（公告）日：2020-02-19

  The invention provides a non-naturally occurring microbial organism having a hexamethylenediamine pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the hexamethylenediamine pathway. The invention additionally provides a method for producing hexamethylenediamine. The method can include culturing a hexamethylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a hexamethylenediamine pathway enzyme in a sufficient amount to produce the hexamethylenediamine, under conditions and for a sufficient period of time to produce hexamethylenediamine.

  本发明提供了一种具有六亚甲基二胺途径的非天然微生物。该微生物含有至少一种编码六亚甲基二胺途径中酶的外源核酸。本发明还提供了一种生产六亚甲基二胺的方法。该方法可包括培养产生六亚甲基二胺的微生物有机体，其中微生物有机体表达至少一种编码六亚甲基二胺途径酶的外源核酸，其数量足以产生六亚甲基二胺，其条件和时间足以产生六亚甲基二胺。
• AMINO ACID HAVING FUNCTIONAL GROUP CAPABLE OF INTERMOLECULAR HYDROGEN BONDING, PEPTIDE COMPOUND CONTAINING SAME AND METHOD FOR PRODUCTION THEREOF
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP3896056A1

  公开（公告）日：2021-10-20

  It has been found that the membrane permeability of peptide compounds can be improved by making at least one of amino acids constituting the peptide compound be an amino acid having a side chain capable of forming an intramolecular hydrogen bond.

  研究发现，通过使构成多肽化合物的氨基酸中至少有一个氨基酸具有能够形成分子内氢键的侧链，可以改善多肽化合物的膜渗透性。
• Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
  申请人：Genomatica, Inc.

  公开号：US10150977B2

  公开（公告）日：2018-12-11

  The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

  本发明提供了一种具有 6-氨基己酸、己内酰胺、六偏二胺或左旋维酸途径的非天然微生物。该微生物有机体含有至少一种外源核酸，该核酸编码相应 6-氨基己酸、己内酰胺、六偏二胺或左旋维酸途径中的酶。本发明还提供了一种生产 6-氨基己酸、己内酰胺、己二胺或乙酰丙酸的方法。该方法可包括培养生产 6-氨基己酸、己内酰胺或六甲撑二胺的微生物有机体，其中微生物有机体表达至少一种编码 6-氨基己酸、己内酰胺或六甲撑二胺的外源核酸、在生产 6-氨基己酸、己内酰胺、己二胺或乙酰丙酸的条件下，表达至少一种编码 6-氨基己酸、己内酰胺、己二胺或乙酰丙酸途径酶的外源核酸，且该酶的量足以生产相应的产品，并能持续足够长的时间。