5,6-二溴吡啶-2-羧酸 | 1206679-66-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5,6-二溴吡啶-2-羧酸
• 中文别名: 5,6-二溴-2-吡啶羧酸
• 英文名称: 5,6-dibromopicolinic acid
• 英文别名: 5,6-dibromopyridine-2-carboxylic acid
• CAS: 1206679-66-4
• 化学式: C₆H₃Br₂NO₂
• 分子量: 280.903
• InChiKey: XKHFYQMPUZAWOA-UHFFFAOYSA-N

物化性质

• 沸点：
  379.5±42.0 °C(Predicted)
• 密度：
  2.202±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  储存条件为2-8°C，并需保存在惰性气体中。

反应信息

• 作为反应物：
  描述：

  5,6-二溴吡啶-2-羧酸 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 水 、 potassium carbonate 、 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 lithium hydroxide 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 2-[Cyclopentyl-(5,6-diphenylpyridine-2-carbonyl)amino]acetic acid
  参考文献：
  名称：

  WO2024009283A1

  摘要：

  公开号：

文献信息

• Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria
  作者：William T. Barker、Courtney E. Chandler、Roberta J. Melander、Robert K. Ernst、Christian Melander

  DOI：10.1016/j.bmc.2019.03.019

  日期：2019.5

  The last three decades have seen a dwindling number of novel antibiotic classes approved for clinical use and a concurrent increase in levels of antibiotic resistance, necessitating alternative methods to combat the rise of multi-drug resistant bacteria. A promising strategy employs antibiotic adjuvants, non-toxic molecules that disarm antibiotic resistance. When co-dosed with antibiotics, these compounds restore antibiotic efficacy in drug-resistant strains. Herein we identify derivatives of tryptamine, a ubiquitous biochemical scaffold containing an indole ring system, capable of disarming colistin resistance in the Gram-negative bacterial pathogens Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli while having no inherent bacterial toxicity. Resistance was overcome in strains carrying endogenous chromosomally-encoded colistin resistance machinery, as well as resistance conferred by the mobile colistin resistance-1 (mcr-1) plasmid-borne gene. These compounds restore a colistin minimum inhibitory concentration (MIC) below the Clinical & Laboratory Sciences Institute (CLSI) breakpoint in all resistant strains.
• 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES
  申请人：Dow Agrosciences LLC

  公开号：EP1246802A1

  公开（公告）日：2002-10-09
• SELECTIVE ELECTROCHEMICAL REDUCTION OF HALOGENATED 4-AMINOPICOLINIC ACIDS
  申请人：Dow AgroSciences LLC

  公开号：EP1248867A1

  公开（公告）日：2002-10-16
• HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2144898A2

  公开（公告）日：2010-01-20
• [EN] 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES<br/>[FR] 4-AMINOPICOLINATES ET LEURS UTILISATIONS COMME HERBICIDES
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2001051468A1

  公开（公告）日：2001-07-19

  4-Aminopicolinic acids, having halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluoromethyl substituents in the 3-, 5- and 6-positions, and their amine and acid derivatives of formula (I) wherein X represents H, halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, nitro, or trifluoromethyl; Y represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, heteroaryloxy or trifluoromethyl; Z represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy or nitro; and W represents -NO2, -N3, -NR1R2, -N=CR3R4 or -NHN=CR3R4 are potent herbicides demonstrating a broad spectrum of weed control.