Eicosa-5,11,14-trienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Eicosa-5,11,14-trienoic acid
• 英文别名: icosa-5,11,14-trienoic acid
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.5
• InChiKey: PRHHYVQTPBEDFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• AMINO ACID SALTS OF UNSATURATED FATTY ACIDS
  申请人：Thetis Pharmaceuticals LLC

  公开号：US20170119841A1

  公开（公告）日：2017-05-04

  The present invention provides compounds of Formula I and Formula II and related compositions and methods.

  本发明提供了Formula I和Formula II的化合物以及相关的组合物和方法。
• Process for producing hydroxylated fatty acids and delta-lactones
  申请人：——

  公开号：US20040197882A1

  公开（公告）日：2004-10-07

  The process which comprises causing cells or a culture of a microorganism having the activity to introduce hydroxy into the [n-5]-position (n is an even number of 10 or more) and hydrogen into the [n-6]-position of a straight-chain fatty acid having n carbon atoms wherein at least the [n-6]-position is a double bond to make the [n-6]-position a single bond or a treated matter thereof to act on a straight-chain fatty acid having n carbon atoms wherein at least the [n-6]-position is a double bond or a composition containing the fatty acid to form an [n-5]-hydroxy fatty acid wherein the [n-6]-position is a single bond, causing cells or a culture of a microorganism having the activity to &bgr;-oxidize an [n-5]-hydroxy fatty acid wherein the [n-6]-position is a single bond or a treated matter thereof to act on the formed [n-5]-hydroxy fatty acid, and recovering the formed &dgr;-lactones.

  该过程包括使用具有将羟基引入n-5位置（n为10或更多的偶数）和氢引入n-6位置的微生物细胞或培养基的活性，作用于直链脂肪酸（其中至少n-6位置为双键），使n-6位置成为单键或处理后的物质，作用于直链脂肪酸（其中至少n-6位置为双键）或含有脂肪酸的组合物，以形成n-5羟基脂肪酸，其中n-6位置为单键，使用具有β-氧化活性的微生物细胞或培养基作用于n-5羟基脂肪酸（其中n-6位置为单键）或处理后的物质，以回收形成的δ-内酯。
• Compositions and Methods Relating to Ionic Salts of Peptides
  申请人：THETIS PHARMACEUTICALS LLC

  公开号：US20160107985A1

  公开（公告）日：2016-04-21

  The present invention relates to compounds of Formula I, compositions containing same, and methods of use.

  本发明涉及式I的化合物，含有该化合物的组合物以及使用方法。
• NMIFA's as anti-inflammatory agents in superficial mammal tissues
  申请人：SOCIETE DES PRODUITS NESTLE S.A.

  公开号：EP0919230A1

  公开（公告）日：1999-06-02

  A topical pharmaceutical or cosmetic composition comprising, as the active ingredient, at least one of the NMIFA's having the following formula, wherein the NMIFA is under the form of an acid, a salt or an ester, and R1 is C1-C5 alkyl and R2 is C2-C6 alkyl, preferably wherein the NMIFA is 20:3(5,11,14). These NMIFA's are used for the preparation of a composition intended to modulate the metabolism of lipids in superficial mammal tissues.

  一种外用药物或化妆品组合物，其活性成分包括至少一种具有下式的 NMIFA，其中 NMIFA 以酸、盐或酯的形式存在，R1 为 C1-C5 烷基，R2 为 C2-C6 烷基，优选 NMIFA 为 20:3(5,11,14)。这些 NMIFA 可用于制备调节哺乳动物表层组织脂质代谢的组合物。
• PROCESS FOR PRODUCING HYDROXYLATED FATTY ACID AND DELTA-LACTONE
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1197560A1

  公开（公告）日：2002-04-17

  The process which comprises causing cells or a culture of a microorganism having the activity to introduce hydroxy into the [n-5]-position (n is an even number of 10 or more) and hydrogen into the [n-6)-position of a straight-chain fatty acid having n carbon atoms wherein at least the [n-6]-position is a double bond to make the [n-6]-position a single bond or a treated matter thereof to act on a straight-chain fatty acid having n carbon atoms wherein at least the [n-6]-position is a double bond or a composition containing the fatty acid to form an [n-5]-hydroxy fatty acid wherein the [n-6]-position is a single bond, causing cells or a culture of a microorganism having the activity to β-oxidize an [n-5]-hydroxy fatty acid wherein the [n-6]-position is a single bond or a treated matter thereof to act on the formed [n-5]-hydroxy fatty acid, and recovering the formed δ-lactones.

  本发明的工艺包括使具有活性的细胞或微生物培养物将羟基引入具有 n 个碳原子的直链脂肪酸的[n-5]位(n 为 10 个或更多的偶数)，并将氢引入具有 n 个碳原子的直链脂肪酸的[n-6]位，其中至少[n-6]位是双键，以使[n-6]位成为单键或其处理物作用于具有 n 个碳原子的直链脂肪酸，其中至少[n-6]位是双键。位为双键，使[n-6]-位成为单键或其处理物作用于具有 n 个碳原子的直链脂肪酸（其中至少[n-6]-位为双键）或含有该脂肪酸的组合物，以形成[n-5]-羟基脂肪酸（其中[n-6]-位为单键）、使具有β-氧化[n-5]-羟基脂肪酸（其中[n-6]-位为单键）活性的细胞或微生物培养物或其处理物作用于形成的[n-5]-羟基脂肪酸，并回收形成的δ-内酯。