N-tert-butyl-2-[2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-tert-butyl-2-[2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
• 化学式: C₃₂H₄₅N₃O₄S
• 分子量: 567.8
• InChiKey: QAGYKUNXZHXKMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Verwendun von Chinoxalinen in Kombination mit Protease-Inhibitoren als Arzneimittel zur Behandlung von AIDS und/oder HIV-Infektionen
  申请人：BAYER AG

  公开号：EP0728481A2

  公开（公告）日：1996-08-28

  Die vorliegende Erfindung betrifft die Verwendung von Chinoxalinen in Kombination mit Protease-Inhibitoren als Arzneimittel zur Behandlung von AIDS und/oder HIV-Infektionen.

  本发明涉及喹喔啉类药物与蛋白酶抑制剂联用作为治疗艾滋病和/或艾滋病毒感染的药物。
• A NOVEL PHARMACEUTICAL COMPOUND AND METHODS OF MAKING AND USING SAME
  申请人：New River Pharmaceuticals Inc.

  公开号：EP1357928A2

  公开（公告）日：2003-11-05
• EP1357928A4
  申请人：——

  公开号：EP1357928A4

  公开（公告）日：2004-12-29
• COMBINATION OF IMMUNOMODULATOR AND ANTI-PATHOGENIC AGENT
  申请人：Nunes, Iseu Da Silva

  公开号：EP2259799B1

  公开（公告）日：2014-03-12
• Combination of Immunomodulator and Anti-Pathogenic Agent
  申请人：Nunes Iseu da Silva

  公开号：US20110028385A1

  公开（公告）日：2011-02-03

  A compound comprising combination of an immunomodulator and to at least one anti-pathogenic agent for treating of facultative or strict infections caused by intracellular microorganisms, the components of the combination or association of substances of the invention, the immunomodulator (proteic aggregate of ammonium and magnesium phospholinoleate-palmitoleate anhydride) and at least one substance with antimicrobial properties can be administered either jointly, simultaneously, consecutively or sequentially, in an appropriate form, according to their chemical properties, and in a dose effective against microorganisms in human and animals.